TREM1 Muddles Myeloid Cell Metabolism and Memory in Old Mice
In peripheral macrophages and microglia, the receptor disrupts glucose metabolism. TREM1-deficient amyloidosis mice also had healthier neurons, better memories.
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CSF Hugs Arteries to Squeeze into the Brain
Cerebrospinal fluid rides the pulses of cerebral arteries to enter the brain and spread into cortical tissue. This supports the existence of a human glymphatic system.
In AD, Effects of Some Genetic Variants Limited to Cell Subtypes
One variant promotes expression of TMEM106b in a subset of excitatory neurons, reducing their numbers. Another boosts ApoE4 in microglia.
Easing Microglial Brakes Alleviates Amyloid Pathology in Mice
An antibody against the inhibitory receptor LILRB4 prevented its binding to ApoE. The upshot? Microglia engulfed more Aβ fibrils and plaque load fell.
Two Paths for TREM2-Positive Microglia: DAM or Senescence?
Scientists find the senescent subtype has a distinct protein signature, but little change in gene expression, causing it to be overlooked in transcriptomic studies.
Axons or Bust: To Reach Neuron Extremities, RNAs Hitch a Ride on Lysosomes
Lysosomes deliver a plethora of mRNA transcripts, including those encoding ribosomal subunits and mitochondrial proteins, to axonal terminals for translation.
Reconceptualizing the BBB: Is It Time to Swap ‘Barrier’ for ‘Border'?
The adaptive nature of the interface between blood and brain led some scientists to envision it more like an actively managed border crossing, not a wall.
Lecanemab Tops Other Antibodies at Binding Soluble Aβ Aggregates
In a head-to-head comparison with aducanumab, gantenerumab, and donanemab, lecanemab demonstrated the highest affinity, especially for smaller aggregates.
Can Heparin Delay Alzheimer’s Disease?
In two hospital systems, people who received heparin were diagnosed with AD a year later than people who never took the anticoagulant.
APP C-Terminal Fragments Stifle Calcium Flow from ER to Lysosomes
Amyloid precursor protein CTFs accumulate in lysosomes adjacent to endoplasmic reticulum. This disrupts calcium flow between the organelles.
X-Chromosome-Wide Association Data Spot Alzheimer’s Loci
XWAS from three research groups identified a dozen genetic loci that may help explain sex differences in AD.
Single-Cell Methylomes Offer Clues to Aging
In mouse brain, mRNA methylation distinguishes cell subtypes and changes with age. One standout: APP. It loses its methyls over time.
Large Neuropathology GWAS Finds Four New Dementia Genes
The analysis of nearly 8,000 brains turned up three genes linked to cerebrovascular disease, and one linked to tangles.
Could New Alzheimer’s Marker p-Tau212 Rival p-Tau217?
In preliminary studies in five cohorts, the two markers have similar diagnostic accuracy, and stain tangles in postmortem brain equally well.
Skin Deep: Punch Biopsies Detect Synucleinopathies
In a small sample set, phosphorylated α-synuclein was detected in the dermis of four such disorders.
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