Sixth Int. Conference on AD: Molecular Interactions in AD Pathogenesis
The "great amyloid debate" appeared to resolve at least one issue in the rather contentious arena of defining the critical neuropathological events in AD...
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Sixth Int. Conference on AD: Mechanisms of Neurodegerative Conditions III
Aβ's fibril-formation processes were revealed in a tour de force of atomic force microscopy by Harper (Abstract 909). The initial species to be detected are four nm globular assemblies...
Sixth Int. Conference on AD: Pathology I
Three abstracts presented during this session, as well as those by Vincent et al. (Abstract 594) and Arendt et al. (Abstract 595), indicate that cell cycle and mitotic mechanisms may be a key factor in the understanding of tau phosphorylation...
Sixth Int. Conference on AD: Towards the Next Generation of AD Therapeutics
This roundtable session, supported by a grant from SmithKline Beecham and cochaired by G. Wilcock (Bristol, UK) and R. Kumar (Essex, UK), sought to provide a glimpse of future directions for the development of new therapeutic agents for AD...
Sixth Int. Conference on AD: Mahley Plenary Lecture
B. Mahley (Abstract 303) reported new data on transgenic mice that could help elucidate the role of ApoE isoforms in neurodegeneration. He began his lecture with an overview of the structure and function of apolipoprotein E (ApoE)...
Sixth Int. Conference on AD: Mechanisms of Neurodegenerative Conditions II
Alonso et al. (Abstract 590) reviewed the role of tau proteins in tubulin polymerization. There are six tau isoforms in the human brain. Three have three microtubule-binding domains (3R) and the three others have four microtubule-binding domains (4R)...
Sixth Int. Conference on AD: Mechanisms of Neurodegenerative Conditions I
Perhaps one of the most striking features of the conference this year, reflecting the state of research on AD in general, is the continued absence of a clear consensus on what is the most relevant neuropathological change in AD...
Sixth Int. Conference on AD: Genetics I
This session was disappointing, offering nothing really new. What new data were presented appear to be very controversial...
Sixth Int. Conference on AD: Cellular/Animal Models I
Soto (Abstract 295) presented data documenting the ability of their 11 and 5 amino-acid inhibitors to inhibit initial Aβ peptide aggregation and its ability to dissociate already formed Aβ fibrils in vitro...
Sixth Int. Conference on AD: Monkey Brain Injections
Bruce Yankner took time out from his talk on Down's syndrome (Abstract 7) to discuss his recent injection studies in young versus aged rhesus monkeys, published in the July issue of Nature Medicine...
Progress in Anti-inflammatory Drugs for Alzheimer's
The brains of Alzheimer's disease victims are peppered with neuritic plaques—microscopic, spherical structures containing, among other things, deposits of β amyloid peptide, dead and dying neurons and evidence of inflammation...
A Role for a Synuclein Protein
Synucleins are small cytoplasmic proteins that are found in synaptic terminals. They are present in senile plaques and Lewy bodies (features of Alzheimer's disease and familial Parkinson's disease)...
Success with Artificial Chromosomes
(From Nature Biotechnology press release.) Each cell in our bodies contains 46 chromosomes. But one day far in the future, doctors may give us an extra miniature chromosome containing therapeutic genes to treat disease...
Transgenic Mouse Mill
Breeding “knockout” mice is a prized tool for evaluating the function of genes, but it is a ponderous and costly tool, consuming many months and thousands of dollars to create each new knockout strain...
New Parkinson’s Gene
A gene on the long arm of chromosome 6 has been linked to an inherited form of Parkinson’s disease, called autosomal recessive juvenile parkinsonism (AR-JP)...
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