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RESEARCH NEWS 2024-10-22 Research News Recent studies suggest that when neurons are overwhelmed by oxidative stress, they spew out toxic, peroxidated lipids. Glia then sail in to mop up the spill, containing the oils within intracellular droplets for use later on as fuel. Tau pla
RESEARCH NEWS 2024-10-22 Research News Four anti-amyloid antibodies— lecanemab, aducanumab, gantenerumab, donanemab —cleared plaque from the brain in Phase 3 trials, but only two went on to receive traditional U.S. marketing approval. What distinguished the successful ones? In a
RESEARCH NEWS 2024-10-20 Research News A drug that has been used for nearly a century to prevent and dissolve blood clots may also delay the onset of Alzheimer’s disease, according to a study in the October 8 Molecular Psychiatry. Heparin may never be prescribed for AD, but the f
COMMUNITY NEWS 2024-10-17 Community News A top researcher’s fall from grace sends shock waves through the scientific community. Such is the case with neuropathologist Eliezer Masliah, who stands accused of image falsification spanning 26 years. Masliah has published more than 800
RESEARCH NEWS 2024-10-17 Research News Geneticists are increasingly turning to endophenotypes, i.e., measurable disease traits, to help uncover genes that might be missed in heterogenous clinical cohorts. In the October 8 Nature Genetics, scientists led by David Fardo at the Univ
RESEARCH NEWS 2024-10-17 Research News Repeat expansion disorders, which are responsible for more than 40 neurological diseases, may be more common than clinical data would suggest. Epidemiological studies had estimated that REDs affect about one in 3,000 people, but now a study
PAPER Gunasekaran TI, Meena D, Lee AJ, Wu S, Dumitrescu L, Sperling R, Hohman TJ, AlzheimersDiseaseNeuroimagingInitiativeandtheA4Study, Huang J, Dehghan A, Tzoulaki I, Mayeux R, Vardarajan B
RESEARCH NEWS 2024-10-14 Research News In neurodegenerative diseases, microglia can help or harm the brain. In the October 3 Journal of Clinical Investigation, scientists led by Ilia Baskakov at the University of Maryland School of Medicine, Baltimore, documented a transition fro
RESEARCH NEWS 2024-10-11 Research News The image of the “blood-brain barrier” as a static wall that shields the brain from the rest of the body is crumbling. A group of scientists argue, in a review published in Fluids and Barriers of the CNS earlier this year, that it’s time to
RESEARCH NEWS 2024-10-11 Research News Far from a static wall, the so-called “blood-brain barrier” is a dynamic, bustling interface that allows select groups of molecules to pass in and out of the brain. Which proteins and nutrients can cross varies according to the needs of the
RESEARCH NEWS 2024-10-06 Research News Scientists are exploring many ways to tackle tau pathology. In the October 17 Cell Chemical Biology, researchers led by Jian-Zhi Wang at the Huazhong University of Science and Technology, Wuhan, China, advocated for a new one. They generated
RESEARCH NEWS 2024-10-05 Research News A new single-cell omics model might help scientists better understand brain function. As reported in the September 24 Nature Neuroscience, researchers led by Kate Meyer, Duke University, Durham, North Carolina, profiled the mRNA methylomes o
RESEARCH NEWS 2024-10-04 Research News Scientists have always presumed that the Aβ in plaques comes solely from neurons. Three recent papers challenge that assumption, identifying another, unexpected source—oligodendrocytes. In the September Nature Neuroscience, scientists led by
PAPER Lam AD, Thibault EG, Mayblyum DV, Hsieh S, Pellerin KR, Sternberg EJ, Viswanathan A, Buss S, Sarkis RA, Jacobs HI, Johnson KA, Sperling RA
RESEARCH NEWS 2024-09-27 Research News When Aβ aggregates stoke synaptic fires, tau tangles put them out. This phenomenon, demonstrated in animal models, now gains support in a human study, published September 18 in Nature Neuroscience. Led by Sylvain Baillet at McGill University
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