SEARCH RESULTS

300519 RESULTS

Perineuronal Pockets Prevent Spillage from Synapses

RESEARCH NEWS 2024-07-23 Research News The latticework of extracellular protein that surrounds brain cells forms a particularly dense mesh around fast-spiking interneurons. Why do these cells need such thick coats? In the July 17 Nature Neuroscience, scientists led by Harald Sont

Part with PILRA, Power Up Microglia?

RESEARCH NEWS 2024-07-19 Research News Ever since loss-of-function variants in the gene for PILRA, short for paired immunoglobulin-like type 2 receptor alpha, turned up as protecting against Alzheimer’s disease, scientists have wondered why. Now, a cell biology “omics” study prof

Do Tau Fibrils Form Via Droplets?

RESEARCH NEWS 2024-07-19 Research News How do tau fibrils develop? In the July 19 Structure online, scientists led by Yoshiyuki Soeda and Akihiko Takashima at Gakushuin University, Tokyo, proposed that the protein first condenses into droplets, then folds into insoluble β sheets.

Do Rod-Shaped Microglia Dampen Hyperexcitability in ALS?

RESEARCH NEWS 2024-07-14 Research News Microglia respond to proteinopathies by changing their shapes and expression profiles in different ways. Here’s one that has been somewhat overlooked: rod-shaped microglia. These long, straight cells have been observed in several neurodegene

C1q from Microglia Meddles in Neuronal Translation

RESEARCH NEWS 2024-07-12 Research News The innate immune protein C1q seems to have a thing for neurons. Already implicated in synaptic pruning by microglia, now it is reported to also slow down protein production in neurons of the aging mouse brain. In the June 24 Cell, researche

A First for Proteinopathies—Heteromeric Fibrils

RESEARCH NEWS 2024-07-05 Research News In recent years, cryo-electron microscopists have unveiled a dazzling array of amyloid filament structures that underlie neurodegenerative diseases. Until now, all of them included but a single protein—Aβ, tau, α-synuclein, TDP-43, and other

Donanemab Approved in the U.S.

COMMUNITY NEWS 2024-07-03 Community News Donanemab has become the second anti-amyloid immunotherapy to win traditional approval from the U.S. Food and Drug Administration. The antibody, which will be marketed as Kisunla, got the official go-ahead July 2. The decision had been wide

PET Tracers For Non-Alzheimer’s Tauopathies Enter Clinical Testing

RESEARCH NEWS 2024-07-03 Research News The current tau PET tracers bind best to the fibrils found in Alzheimer’s disease, and now, finally, comes progress on non-AD tauopathies. In the June 14 Nature Communications, researchers led by Neil Vasdev at the University of Toronto, in

Remember Amyloid-eta? A Decade Later, News on a Physiological Function

RESEARCH NEWS 2024-06-30 Research News Aη, or A-eta, made an initial splash when scientists reported that these fragments of amyloid precursor protein—products of a heretofore unknown cleavage—dampen neural activity. But how? The story went quiet. Nine years later, comes a possib

T Cells in the Brain Goad Microglia to Muddle Myelin

RESEARCH NEWS 2024-06-28 Research News The idea that infiltrating T cells contribute to a neurodegenerative environment in aging and in Alzheimer’s disease has gotten another boost. In the June 27 Nature Neuroscience, scientists led by Mikael Simons, Technical University Munich,

Current Filters

No filters selected

Filter By

DATE RANGE
  • All
  • Past 7 Days
  • Past 30 Days
  • Past 90 Days
  • Past 12 Months
  • Specific Dates
    1. From
      To

TYPE