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RESEARCH NEWS 2024-02-21 Research News Type 2 diabetes (T2D) raises a person’s risk of developing dementia by about 50 percent. Does tightly controlling blood sugar decrease that risk? Yes, according to researchers led by Eng-Kiong Yeoh and Kailu Wang at the Chinese University of
RESEARCH NEWS 2024-02-18 Research News Recent proteomic studies have offered glimpses into the biology of early Alzheimer’s disease. Two new preprints take this approach further, describing high-throughput surveys that turned up numerous new candidate biomarkers. In one, posted t
RESEARCH NEWS 2024-02-16 Research News Immune cells in the blood may be intimately involved with Alzheimer’s pathogenesis in the brain. At least, according to their chromatin. A study published January 31 in Neuron reported that in people with AD, the circulating cells—especially
RESEARCH NEWS 2024-02-16 Research News Five years ago, scientists described a deletion of six amino acids within the APP gene, reporting that three members of a Swedish family, who each carried one copy of this “ Uppsala deletion,” developed Alzheimer’s disease in their early 40s
PAPER Lan G, Chen X, Yang J, Sun P, Cai Y, Li A, Zhu Y, Liu Z, Ma S, Guo T, Alzheimer's Disease Neuroimaging Initiative
RESEARCH NEWS 2024-02-09 Research News Cerebrospinal fluid washes waste from the brain, eventually draining into the lymph nodes and bloodstream—but exactly how this flow bypasses the brain’s barriers to reach the periphery has remained somewhat mysterious. In the February 7 Natu
RESEARCH NEWS 2024-02-08 Research News Progressive supranuclear palsy, a rare tauopathy, slowly destroys a person's cognition, balance, and movement. PSP ranks second behind Parkinson’s disease as a cause of Parkinsonism. Beyond variants in the tau gene, a handful of other r
COMMUNITY NEWS 2024-02-01 Community News Biogen has thrown in the towel on its controversial anti-amyloid antibody aducanumab. The company announced January 31 that it would stop all development of the drug, and halt the post-market, confirmatory Envision trial. Biogen said it mad
RESEARCH NEWS 2024-02-01 Research News Twelve years ago, clinicians gathered in Vancouver, Canada, for the first international working group meeting on posterior cortical atrophy. At the time, PCA was obscure. It lacked consensus on clinical diagnostic criteria, biomarkers, and e
RESEARCH NEWS 2024-02-01 Research News The structure of ApoE has proven tricky to discern in its native state, namely, attached to lipoproteins. Now, scientists led by David Holtzman at Washington University in St. Louis have captured lipidated ApoE at its highest resolution yet.
RESEARCH NEWS 2024-01-31 Research News Research over the last decade has shown that aggregated Aβ seeds can be transferred between people during rare medical procedures, sparking amyloidosis in the recipient. Could this result in full-blown Alzheimer’s disease? In the January 29
PAPER Banerjee G, Farmer SF, Hyare H, Jaunmuktane Z, Mead S, Ryan NS, Schott JM, Werring DJ, Rudge P, Collinge J
RESEARCH NEWS 2024-01-26 Research News Part 2 of 2. Click here for Part 1. What happens in the brain of a person with fatal ARIA? Researchers now have one of their first detailed looks at the pathology of this rare and calamitous condition. In the December 12 Nature Communication
RESEARCH NEWS 2024-01-19 Research News When people come to their doctor with memory problems, they tend to want to know if Alzheimer's is to blame and, if so, what they can expect. Answering these questions with a degree of certainty is a tall order, and many view amyloid-PE
RESEARCH NEWS 2024-01-17 Research News Some scientists believe that toxic tau fibrils hop between synapses to spread throughout the brain, prompted by Aβ aggregates and overactive neurons. New imaging and biomarker data add weight to this theory. In the January 3 Nature Communica
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