PAPER Gertsik N, Chau DM, Li YM

γ-Secretase Inhibitors and Modulators Induce Distinct Conformational Changes in the Active Sites of γ-Secretase and Signal Peptide Peptidase.

ACS Chem Biol. 2015 Aug 21;10(8):1925-31. Epub 2015 Jun 10 PubMed.

PAPER Nguyen MT, Van Kersavond T, Verhelst SH

Chemical Tools for the Study of Intramembrane Proteases.

ACS Chem Biol. 2015 Nov 20;10(11):2423-34. Epub 2015 Nov 5 PubMed.

PAPER Abdul-Hay SO, Bannister TD, Wang H, Cameron MD, Caulfield TR, Masson A, Bertrand J, Howard EA, McGuire MP, Crisafulli U, Rosenberry TR, Topper CL, Thompson CR, Schürer SC, Madoux F, Hodder P, Leissring MA

Selective Targeting of Extracellular Insulin-Degrading Enzyme by Quasi-Irreversible Thiol-Modifying Inhibitors.

ACS Chem Biol. 2015 Dec 18;10(12):2716-24. Epub 2015 Sep 30 PubMed.

PAPER Dixon AS, Schwinn MK, Hall MP, Zimmerman K, Otto P, Lubben TH, Butler BL, Binkowski BF, Machleidt T, Kirkland TA, Wood MG, Eggers CT, Encell LP, Wood KV

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells.

ACS Chem Biol. 2016 Feb 19;11(2):400-8. Epub 2015 Dec 10 PubMed.

PAPER Lewis YE, Abeywardana T, Lin YH, Galesic A, Pratt MR

Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α-Synuclein Aggregation and Toxicity.

ACS Chem Biol. 2016 Apr 15;11(4):931-42. Epub 2016 Jan 12 PubMed.

PAPER Martin MD, Baker JD, Suntharalingam A, Nordhues BA, Shelton LB, Zheng D, Sabbagh JJ, Haystead TA, Gestwicki JE, Dickey CA

Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules.

ACS Chem Biol. 2016 Jul 15;11(7):2041-8. Epub 2016 May 26 PubMed.

PAPER Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D

Semisynthetic and in Vitro Phosphorylation of Alpha-Synuclein at Y39 Promotes Functional Partly Helical Membrane-Bound States Resembling Those Induced by PD Mutations.

ACS Chem Biol. 2016 Sep 16;11(9):2428-37. Epub 2016 Jul 11 PubMed.

PAPER Stratton CF, Poulin MB, Du Q, Schramm VL

Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N-Methyltransferase.

ACS Chem Biol. 2017 Feb 17;12(2):342-346. Epub 2016 Dec 28 PubMed.

PAPER Lewis YE, Galesic A, Levine PM, De Leon CA, Lamiri N, Brennan CK, Pratt MR

O-GlcNAcylation of α-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding.

ACS Chem Biol. 2017 Apr 21;12(4):1020-1027. Epub 2017 Feb 22 PubMed.

PAPER Soper-Hopper MT, Eschweiler JD, Ruotolo BT

Ion Mobility-Mass Spectrometry Reveals a Dipeptide That Acts as a Molecular Chaperone for Amyloid β.

ACS Chem Biol. 2017 Apr 21;12(4):1113-1120. Epub 2017 Mar 6 PubMed.

PAPER Jones CL, Njomen E, Sjögren B, Dexheimer TS, Tepe JJ

Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins.

ACS Chem Biol. 2017 Sep 15;12(9):2240-2247. Epub 2017 Aug 1 PubMed.

PAPER Chiang WC, Wei Y, Kuo YC, Wei S, Zhou A, Zou Z, Yehl J, Ranaghan MJ, Skepner A, Bittker JA, Perez JR, Posner BA, Levine B

High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding.

ACS Chem Biol. 2018 Aug 17;13(8):2247-2260. Epub 2018 Jun 21 PubMed.

PAPER Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SI, Mannini B, Barbut D, Nollen EA, Cecchi C, Cremades N, Knowles TP, Chiti F, Zasloff M, Vendruscolo M, Dobson CM

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

ACS Chem Biol. 2018 Aug 17;13(8):2308-2319. Epub 2018 Jun 28 PubMed.

PAPER Cascella R, Perni M, Chen SW, Fusco G, Cecchi C, Vendruscolo M, Chiti F, Dobson CM, De Simone A

Probing the Origin of the Toxicity of Oligomeric Aggregates of α-Synuclein with Antibodies.

ACS Chem Biol. 2019 Jun 21;14(6):1352-1362. Epub 2019 May 14 PubMed.

PAPER Despres C, Di J, Cantrelle FX, Li Z, Huvent I, Chambraud B, Zhao J, Chen J, Chen S, Lippens G, Zhang F, Linhardt R, Wang C, Klärner FG, Schrader T, Landrieu I, Bitan G, Smet-Nocca C

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors.

ACS Chem Biol. 2019 Jun 21;14(6):1363-1379. Epub 2019 May 15 PubMed.