PAPER Bocharov EV, Nadezhdin KD, Urban AS, Volynsky PE, Pavlov KV, Efremov RG, Arseniev AS, Bocharova OV

Familial L723P Mutation Can Shift the Distribution between the Alternative APP Transmembrane Domain Cleavage Cascades by Local Unfolding of the Ε-Cleavage Site Suggesting a Straightforward Mechanism of Alzheimer's Disease Pathogenesis.

ACS Chem Biol. 2019 Jul 19;14(7):1573-1582. Epub 2019 Jun 19 PubMed.

PAPER Laine RF, Sinnige T, Ma KY, Haack AJ, Poudel C, Gaida P, Curry N, Perni M, Nollen EA, Dobson CM, Vendruscolo M, Kaminski Schierle GS, Kaminski CF

Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans.

ACS Chem Biol. 2019 Jul 19;14(7):1628-1636. Epub 2019 Jun 27 PubMed.

PAPER Pansieri J, Ostojić L, Iashchishyn IA, Magzoub M, Wallin C, Wärmländer SK, Gräslund A, Nguyen Ngoc M, Smirnovas V, Svedružić Ž, Morozova-Roche LA

Pro-Inflammatory S100A9 Protein Aggregation Promoted by NCAM1 Peptide Constructs.

ACS Chem Biol. 2019 Jul 19;14(7):1410-1417. Epub 2019 Jun 13 PubMed.

PAPER Vivoli Vega M, Cascella R, Chen SW, Fusco G, De Simone A, Dobson CM, Cecchi C, Chiti F

The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure.

ACS Chem Biol. 2019 Jul 19;14(7):1593-1600. Epub 2019 Jul 5 PubMed.

PAPER François-Moutal L, Felemban R, Scott DD, Sayegh MR, Miranda VG, Perez-Miller S, Khanna R, Gokhale V, Zarnescu DC, Khanna M

Small Molecule Targeting TDP-43's RNA Recognition Motifs Reduces Locomotor Defects in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS).

ACS Chem Biol. 2019 Sep 20;14(9):2006-2013. Epub 2019 Aug 27 PubMed.

PAPER Pan B, Rhoades E, Petersson EJ

Chemoenzymatic Semisynthesis of Phosphorylated α-Synuclein Enables Identification of a Bidirectional Effect on Fibril Formation.

ACS Chem Biol. 2020 Mar 20;15(3):640-645. Epub 2020 Feb 17 PubMed.

PAPER Ramirez DH, Aonbangkhen C, Wu HY, Naftaly JA, Tang S, O'Meara TR, Woo CM

Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells.

ACS Chem Biol. 2020 Apr 17;15(4):1059-1066. Epub 2020 Mar 2 PubMed.

PAPER Sachsenhauser V, Deng X, Kim HH, Jankovic M, Bardwell JC

Yeast Tripartite Biosensors Sensitive to Protein Stability and Aggregation Propensity.

ACS Chem Biol. 2020 Apr 17;15(4):1078-1088. Epub 2020 Mar 10 PubMed.

PAPER Bilousova T, Simmons BJ, Knapp RR, Elias CJ, Campagna J, Melnik M, Chandra S, Focht S, Zhu C, Vadivel K, Jagodzinska B, Cohn W, Spilman P, Gylys KH, Garg NK, John V

Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease.

ACS Chem Biol. 2020 Jun 19;15(6):1671-1684. Epub 2020 May 14 PubMed.

PAPER Newberry RW, Arhar T, Costello J, Hartoularos GC, Maxwell AM, Naing ZZ, Pittman M, Reddy NR, Schwarz DM, Wassarman DR, Wu TS, Barrero D, Caggiano C, Catching A, Cavazos TB, Estes LS, Faust B, Fink EA, Goldman MA, Gomez YK, Gordon MG, Gunsalus LM, Hoppe N, Jaime-Garza M, Johnson MC, Jones MG, Kung AF, Lopez KE, Lumpe J, Martyn C, McCarthy EE, Miller-Vedam LE, Navarro EJ, Palar A, Pellegrino J, Saylor W, Stephens CA, Strickland J, Torosyan H, Wankowicz SA, Wong DR, Wong G, Redding S, Chow ED, DeGrado WF, Kampmann M

Robust Sequence Determinants of α-Synuclein Toxicity in Yeast Implicate Membrane Binding.

ACS Chem Biol. 2020 Aug 21;15(8):2137-2153. Epub 2020 Aug 12 PubMed.

PAPER Mollasalehi N, Francois-Moutal L, Scott DD, Tello JA, Williams H, Mahoney B, Carlson JM, Dong Y, Li X, Miranda VG, Gokhale V, Wang W, Barmada SJ, Khanna M

An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties.

ACS Chem Biol. 2020 Nov 20;15(11):2854-2859. Epub 2020 Oct 12 PubMed.

PAPER Krishnan N, Chen X, Donnelly-Roberts D, Mohler EG, Holtzman DM, Gopalakrishnan SM

Small Molecule Phenotypic Screen Identifies Novel Regulators of LDLR Expression.

ACS Chem Biol. 2020 Dec 18;15(12):3262-3274. Epub 2020 Dec 3 PubMed.

PAPER Ursu A, Wang KW, Bush JA, Choudhary S, Chen JL, Baisden JT, Zhang YJ, Gendron TF, Petrucelli L, Yildirim I, Disney MD

Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD.

ACS Chem Biol. 2020 Dec 18;15(12):3112-3123. Epub 2020 Nov 16 PubMed.

PAPER Galesic A, Rakshit A, Cutolo G, Pacheco RP, Balana AT, Moon SP, Pratt MR

Comparison of N-Acetyl-Glucosamine to Other Monosaccharides Reveals Structural Differences for the Inhibition of α-Synuclein Aggregation.

ACS Chem Biol. 2021 Jan 15;16(1):14-19. Epub 2021 Jan 5 PubMed.

PAPER Wang P, Zhao J, Hossaini Nasr S, Otieno SA, Zhang F, Qiang W, Linhardt RJ, Huang X

Probing Amyloid β Interactions with Synthetic Heparan Sulfate Oligosaccharides.

ACS Chem Biol. 2021 Feb 16; PubMed.