‛iNET’ Cultures Expose NPTX2 as TDP-43 Henchman
A new, stem-cell-based method generated neural cultures that live long enough to suffer the consequences of TDP-43 dysregulation.
ALL NEWS
6122 RESULTS
Sort By:
- Most Recent
- Most Commented
In Diabetes, Tight Blood Sugar Control Staves Off Dementia
People receiving personalized Type 2 diabetes management were 28 percent less likely to develop dementia, and 15 percent less likely to get Alzheimer's.
Proteomics Uncovers Potential Markers of Early Autosomal Dominant AD
A large, unbiased study found 125 proteins in the CSF that tick up or down in early familial AD. A set of nine identified FAD mutation carriers better than did Aβ and tau.
Epigenetic Shenanigans—In AD, Chromatin Opens Up in Blood Immune Cells
In CD8+ T cells and monocytes, DNA was more accessible in people with AD and even more so in ApoE4 carriers.
Under the Radar: APP Uppsala Fibrils Evade Microglia, PiB, Leqembi
In mice, these Aβ fibrils avoid riling microglia and astrocytes. They also evade both PiB and lecanemab.
Meningeal Cuffs Around Veins Form Exit and Entry Ramps to the Brain
Using live imaging in mice, scientists found that tracers and immune cells move between brain and dura through gaps in the arachnoid mater around veins.
First Whole-Genome Sequencing of PSP Nets Six New Risk Loci
ApoE2 reported as raising risk for progressive supranuclear palsy, a rare tauopathy.
Adieu to Aduhelm: Biogen Stops Marketing Antibody
The company announced it would halt its post-market trial and stop selling the drug; the rights to it now revert to Swiss company Neurimmune.
Posterior Cortical Atrophy Is a Form of Young-Onset Alzheimer’s
Among 1,092 people with PCA, symptoms started around age 60, and 94 percent had amyloid plaques or neurofibrillary tangles.
In Lipoparticles, ApoE Double Belt Keeps the Fat In
The α-helical chains of two ApoEs wrap around lipoprotein discs. They circle in opposite directions.
First Evidence for Transmitted Alzheimer’s Disease?
Eight adults who, as children, had received growth hormone from cadavers developed cognitive problems and/or AD-like pathology in midlife.
Brain of Woman Who Died on Leqembi Shows Worst-Case Scenario
The patient, an APOE4 homozygote with severe cerebral amyloid angiopathy, developed vascular inflammation and bleeding throughout her brain.
FDA Approves BrainSee, AI Software That Purportedly Predicts AD
The software could improve prognosis, speed referrals, for people with MCI, the developer claims.
Mind the GAP—Synaptic Protein in CSF Signals Tau Spread
Growth-associated protein 43 in the CSF identified people who accumulated tangles fastest. These spread through connected brain regions.
Not So Fast—The Brain Has Three Meningeal Membranes After All
Using live imaging, electron microscopy, and gene expression studies, two groups show that a purported fourth membrane is instead the inner layer of the arachnoid mater.
Current Filters
No filters selected