Michele Vendruscolo on Sylvain Lesné, Who Found Aβ*56, Accused of Image Manipulation

COMMENT The positive aspect of this story is that it has refocused the discussion on the role of Aβ oligomers in the amyloid hypothesis. Although at least some among these heterogeneous assemblies are likely to be neurotoxic, it has been extremely difficult to ob

Jason Ulrich on Does Tangle Progression Follow ApoE Expression?

COMMENT It is very interesting that APOE expression came up in this study as being associated with the spread of tau pathology. This observation tracks with some recent studies from our group that found reducing APOE levels through antisense oligonucleotides or r

Colin Masters on Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice.

COMMENT The authors are on the right track, with some success in lowering the Aβ amyloid load after three months treatment, starting at three months of age. The pharmacokinetics of verubecestat ad libitum in mouse chow proved difficult, with sex differences compl

Mathias Jucker on Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer’s disease

COMMENT From en route to AAIC: This is a very cool paper overall. It’s not totally new, but I really enjoyed reading this work, and the findings makes sense to me. 0 mathias.jucker

Thomas Bayer on Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer’s disease

COMMENT Li et al. have convincingly demonstrated that different forms of Aβ can trigger Aβ aggregation into amyloid plaques using human brain-derived amyloid preparations. They observed that full-length Aβ triggers early plaque development and spread, whereas N-t

Lary Walker on Seeding, maturation and propagation of amyloid β-peptide aggregates in Alzheimer’s disease

COMMENT Xiaohang Li, Dietmar Thal, and their colleagues nicely demonstrate that the pathobiology of aggregating Aβ is an evolving process, changing as Alzheimer's disease progresses in different parts of the brain. Using an exogenous seeding paradigm, they f

Eric Siemers, Erika Cline, Jasna Jerecic on Sylvain Lesné, Who Found Aβ*56, Accused of Image Manipulation

COMMENT comments in this article in Alzforum, other laboratories could not replicate the results from Dr. Lesné,

Michael R. Duggan, Keenan Walker on Receptor Decoy Raises Risk of Alzheimer’s—But Only in Women

COMMENT These findings highlight an important endogenous mechanism capable of influencing Aβ clearance among those most at risk of dementia, namely female APOEε4 carriers. Through an integrative and comprehensive multidisciplinary approach, this work led by Nancy

Oskar Hansson on Receptor Decoy Raises Risk of Alzheimer’s—But Only in Women

COMMENT This study is comprehensive and impressive. If the main results of the study are validated in additional well-characterized, longitudinal cohort studies, sST2 might be an interesting new drug target, especially for females with AD. To me, it would be very

Renzo Mancuso on Receptor Decoy Raises Risk of Alzheimer’s—But Only in Women

COMMENT This comprehensive paper goes from clinical observations and genetics to proof of concept in experimental models. One exciting thing about it: It showcases how complicated Alzheimer’s disease is. The authors describe cross talk between endothelial cells a

Elena Galea on Don’t Name It: Glial States Confound Easy Labels

COMMENT I want to elaborate on the suggestion in both articles, on which I am an author, to avoid simplistic binary classifications, such as homeostatic versus activated or neuroprotective versus neurotoxic, when describing the reactions of microglia and astrocyt

Ilya Bezprozvanny on Sylvain Lesné, Who Found Aβ*56, Accused of Image Manipulation

COMMENT This is a shocking story to many as discussed in comments above, mostly because of respect in the

Gerhard Multhaup on Sylvain Lesné, Who Found Aβ*56, Accused of Image Manipulation

COMMENT Among the comments already posted to this news, the most salient to my mind are those of Colin

Dominic Walsh on Sylvain Lesné, Who Found Aβ*56, Accused of Image Manipulation

COMMENT The news story about fabrication of results by Sylvain Lesné is both disturbing and sad. Above all else, science should be about the pursuit of truth. While it is excusable to misinterpret results, it is totally unacceptable to falsify data. A basic tenet

Carsten Korth, Andreas Müller-Schiffmann on Sylvain Lesné, Who Found Aβ*56, Accused of Image Manipulation

COMMENT one 16 (!) years after its publication, or reading repeatedly in the comments that this finding was