Amyloid Not an Aberration?
Aggregated proteins, or amyloids, are seen in a wide variety of neurodegenerative diseases, including Alzheimer's and Creutzfeldt-Jakob (CJD) disease. Such aggregates are generally considered to be aberrant formations...
ALL NEWS
6122 RESULTS
Sort By:
- Most Recent
- Most Commented
FDA Approved Reminyl® for the Treatment of Mild AD
On February 28, 2001, the U.S. Food and Drug Administration (FDA) approved Reminyl® (galantamine hydrobromide) for the treatment of mild to moderate Alzheimer's disease...
β-Secretase a Clean Therapeutic Target
The most promising target for an Alzheimer's therapy in the short term may be the enzyme β-secretase, suggest two papers in the March issue of Nature Neuroscience. Two separate groups have found that mice lacking the BACE1...
Defect in Iron Metabolism Leads to Neurodegeneration
Deleting a critical gene for iron metabolism leads to selective neurodegeneration, according to a study in this month's Nature Genetics. When researchers ablated the gene for iron regulatory protein 2 (IRP2), they produced...
Patients Sought for Nutritional Supplement Clinical
The Memory Evaluation and Treatment Service at Burke Medical Research Institute has started a therapeutic trial of a nutritional supplement...
Patients Being Recruited for Phase I Growth Factor Trial
A Phase I clinical trial of growth factor gene therapy for Alzheimer's disease is currently in progress at the University of California, San Diego...
Exelon Dose Revised
According to a "Dear Healthcare Provider" letter dated January 26 and posted this week on the Web site of the U.S. Food and Drug Administration, patients who take breaks in Exelon...
Neurogenin Suppresses Astrocyte Differentiation
Stem cell researchers know only too well that most adult neural precursor cells differentiate into astrocytes, not the coveted nerve cells. Even when stimulated by the addition of neuron-inducing growth factors...
AF102B (Cevimeline or Evoxac) Lowers CSF Aβ in Alzheimer Patients
A drug currently approved by the FDA for the treatment of dry mouth in Sjogren's syndrome (an autoimmune disease that affects excorine glands) has been shown to reduce levels of amyloid-β...
Neprilysin Steps out of the Shadows
The enzyme neprilysin—capable of degrading Aβ42 peptide—is a new player in the Alzheimer's disease mystery. Writing in Neuroscience Letters, Patrick McGeer's group at the University of British Columbia adds critical circumstantial evidence...
Study Finds Treatments for Agitation Are Inadequate
The drugs haloperidol or trazodone, or behavior management techniques (BMT), are commonly used to treat agitation in Alzheimer's patients...
Glia May Regulate Synaptic Formation and Transmission
Glial cells quietly play a much bigger role than ever imagined, according to an article in today's issue of Science. Ben Barres and colleagues at Stanford report that astrocytes exert a powerful influence on communication between neurons...
Part II: News Summary from American Society for Cell Biology Meeting
James Bamburg presented a poster (Abstract 2821) on the formation of cellular inclusions composed of actin-depolymerizing factor (ADF) and the cofilin family of proteins (collectively known as AC) and of their putative involvement in neurodegeneration...
American Society for Cell Biology: 40th Annual Meeting
News Summary from the 40th Annual Meeting of The American Society for Cell Biology Part II: News Summary from American Society for Cell Biology Meeting American Society for Cell Biology: 2000 Annual Meeting
GFAP Mutation in Alexander's Disease
The cause of Alexander's disease, a very rare, inherited CNS disorder, has been traced to the gene for glial fibrillary acidic protein (GFAP), according to a report published in this month's Nature Genetics...
Current Filters
No filters selected