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Two immune proteins found in the brains of mice help the brain develop and may play key roles in triggering developmental disorders like dyslexia and neurodegenerative disorders like Parkinson's disease...
Mutations in the genes for α-synuclein and parkin have been linked to early-onset Parkinsonism, but the role of genetics in the far more common late-onset disease has been less clear...
Undifferentiated cells from the adult spinal cord can generate neurons when transplanted to the adult hippocampus, reveal Fred Gage and his coworkers at the Salk Institute, California, in the current issue of the Journal of Neuroscience...
The meeting in New Orleans demonstrated that the biology of α-synuclein and parkin are progressing at a rapid pace...
Macrophage activity is thought to play a key role in Alzheimer's and some other neurodegenerative diseases, such as ALS, as well as in autoimmune disorders. The mechanisms that regulate macrophages could...
Statins have recently appeared on the radar screen for Alzheimer's researchers because of studies by Ben Wolozin and his colleagues showing that people who take the cholesterol-lowering drugs have a significantly reduced risk of Alzheimer's disease...
The abnormal prion protein, but not the normal prion protein, binds with high affinity to plasminogen, a plasma component that has been linked to neurotoxicity, according to a report in the current Nature...
Last year, Brad Hyman’s group reported on their ability to image amyloid plaques in the brains of live PDAPP Tg mice. Plaques could be detected as deep as 200 microns and the same plaques could be imaged...
Several presentations focused on the role of presenilins in calcium signaling pathways. Leissring and LaFerla (Abstract 474.7) reported that cells from mutant PS1 knockin mice are deficient in capacitative calcium entry...
What is the latest on the immunization of mice and men with Aβ? Will we be celebrating victory over Alzheimer’s disease in a few years (and looking for new jobs), or has the story been overrated?...
CD40 is a member of the TNF receptor superfamily, which includes TNFR-1, TNFR-2, Fas, CD27, RANK, DR4 (TRAIL-R1), DR5 (TRAIL-R2), and DR6, as well as assorted decoy receptors (e.g., DcR-1/TRAIL-3)...
A current working hypothesis in the field of AD research is that preventing the accumulation of Aß peptides will slow or prevent cognitive decline. Two main strategies for accomplishing this goal have been pursued in recent years...
One of the most daunting tasks facing attendees of this gigantic neuroscience data exchange (dare I say "flea market"?) is identifying signals in the noise (speaking both scientifically and literally). One approach is to sit through slide sessions...
In today's Journal of Cell Biology, researchers of the University of Maryland Biotechnology Institute (UMBI) report that a molecule called ubiquilin regulates levels of presenilins, and is "highly expressed" in human neurons...
What do ßamyloid, buckyballs, and dark matter have in common? They were all mentioned in an intriguing presentation by Dr. Westlind-Danielsson (AstraZeneca, Abstract 299.2) on the formation of spheroidal "supramolecular structures"...
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