New Substrate for Parkin Links Disease to ER Stress
Researchers at Japan's Juntendo University School of Medicine report in tomorrow's Cell that they have identified a novel substrate for the parkin E3 ligase function...
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Direct Functional Link Found for Two Parkinson Genes
The two most prominent genes linked to inherited, monogenic Parkinson's disease—α-synuclein and parkin—are generally thought to be unconnected to each other because the forms of PD they cause are clinically and neuropathologically different...
γ-Secretase and Notch: Inhibitor Hits Both, Impairs T Cell Development
The γ-secretase enzyme activity is a therapeutic target in Alzheimer's disease. Yet its promise of lowering the Aβ42 burden has been under a cloud since1999, when Bart De Strooper and other scientists found that the enzyme...
Huntingtin Regulates BDNF
The gene mutation that causes Huntington's disease has been known for many years, yet the function of the encoded protein, huntingtin, and the pathogenic mechanism of the mutant protein, have remained frustratingly elusive...
In Fly Model of Tauopathy, Neurons Degenerate Without Tangles
Harvard researchers have expressed the wildtype and mutant forms of human tau protein in Drosophila, creating a new model for one aspect of Alzheimer’s disease pathology as well as for tauopathies...
New Prion Detection Method
Abnormal forms of the prion protein are thought to be the infective agent responsible for bovine spongiform encephalopathy (BSE, or "mad cow disease") and its human form, variant Creutzfeldt-Jakob disease (vCJD)...
Lack of Macrophage Protein Protects ApoE-Knockout Mice from Atherosclerosis
Obesity and its frequent cousin, insulin-resistant diabetes, so clearly increase the risk for atherosclerosis that the whole disease complex has been called metabolic syndrome...
New Gene Suspect for ALS
Amyotrophic lateral sclerosis (ALS; also known as Lou Gehrig's disease) is the most common motor neuron disease in humans, affecting one in 1,000. It results in a progressive loss of motor neuron function, leading to...
Protein Aggregates Block Disposal Mechanism
Aggregates of proteins are a common feature in many neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's, fronto-temporal dementia and ALS...
Neprilysin Role in Amyloid Clearance
While much Alzheimer's research has focused on mechanisms that result in the formation of amyloid plaques, a growing body of evidence indicates that processes that break down Aβ are just as important...
The Switch That Turns on Neural Stem Cell Differentiation?
A study in the June issue of Nature Neuroscience points a finger at proteins of the Shc family as the critical link in signaling neural stem cells to either remain in their pluripotent form or differentiate into mature neurons...
Immunological and Neuromuscular Synapses Share Ingredient
The aggregating protein called agrin is a component of two quite different types of synapses: synapses in the neuromuscular junction and the immunological synapse between T cells and antigen-presenting cells...
D'Adamio Is This Year's Alzheimer Award Winner
The Journal of Alzheimer's Disease has awarded the 2001 Alzheimer Medal to Luciano D'Adamio for his article, "Generation of an apoptotic intracellular peptide by γ-secretase cleavage of Alzheimer's amyloid-β protein precursor,"...
Molecules for Remote Memories
Permanent memories are thought to be stored in the cortex, but little is known about the processes that incorporate memories into cortical . Now Alcino J. Silva and colleagues, have discovered a molecular manipulation that affects memory...
Mismatch Between Gene and Protein Sequence Data
The path from identifying a genome sequence to pinpointing the contribution of each gene is beset with pitfalls. In a Brief Communication [in today's Nature], researchers describe discrepancies...
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