Guo X, Li H, Yan C, Lei J, Zhou R, Shi Y. Molecular mechanism of substrate recognition and cleavage by human γ-secretase. Science. 2024 Jun 7;384(6700):1091-1095. Epub 2024 Jun 6 PubMed.

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News

  1. Caught in the Act: Cryo-EM Exposes γ-Secretase Catalytic Pose

Mutations

  1. PSEN1 Y115H
  2. PSEN1 Y115D
  3. PSEN1 Y115C
  4. PSEN1 W165G
  5. PSEN1 W165C (G>C)
  6. PSEN1 S169P
  7. PSEN1 S169L
  8. PSEN1 M233T
  9. PSEN1 F237I
  10. PSEN1 F237L
  11. PSEN1 G384A
  12. PSEN1 S169del (S170del)
  13. PSEN1 W165C (G>T)
  14. PSEN1 F237C