Organization of Aβ Plaques and Tau Tangles Illuminated in AD Brain
Plaques comprise different-sized fibrils and cell membrane components, while tangles have distinct fibril structures segregated into intra- and extracellular compartments.
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Shrunken FDA Advisory Committee Is Unanimous: Leqembi Works
The panel was persuaded of the antibody’s clinical efficacy and overall favorable benefit/risk ratio, although it had questions about risk in certain subgroups.
And Then There Were Three: Donanemab Phase 3 Trial Positive
The antibody slowed decline by 35 percent, met secondary endpoints, will likely be approved. Major question: How to avoid severe ARIA.
Legacy of A4 Secondary Prevention Study Goes Beyond Negative Result
The decade-long trial found no benefit for solanezumab in delaying progression, but laid the groundwork for subsequent prevention studies.
No Easy Answers on Clinical Meaningfulness of Alzheimer’s Treatments
Meaningfulness must account for the disease stage a patient is at, his or her priorities, and effects over time, researchers say.
No Accelerated Approval for Donanemab
The FDA turned down Eli Lilly’s application based on insufficient safety data, with fewer than 100 people on the drug for one year.
And Then There Were Four: A New Meningeal Membrane Discovered
The lymphatic-like membrane blankets blood vessels in the subarachnoid space and harbors immune cells.
Dare We Say Consensus Achieved: Lecanemab Slows the Disease
Scientists at CTAD found the Phase 3 trial well-done, the data consistent, and expect the drug to be approved. Priorities: grow the effect, understand the bleeding risk.
Finally: Big Win on All Outcomes for Lecanemab in Phase 3 Topline Results
Drug sponsors Eisai and Biogen said they will apply for approval in Europe, the U.S., and Japan; more detailed data will be presented at CTAD.
Does Tangle Progression Follow ApoE Expression?
Correlating PET imaging with spatial transcriptomics revealed paths for the progression of tau pathology throughout the brain.
Behold, Plaques Mapped in Whole Brain at High Resolution
Advances in microscopy yield unprecedented views of Aβ plaques in vivo and ex vivo. The vistas offer new insights about how plaques form, grow, and clear.
Receptor Decoy Raises Risk of Alzheimer’s—But Only in Women
High sST2, an IL-33 receptor fragment, raises the odds of Alzheimer’s in women who carry APOE4. A variant that lowers sST2 mobilizes microglia, protects against AD.
Sylvain Lesné, Who Found Aβ*56, Accused of Image Manipulation
Other scientists found indications of potentially doctored western blots in multiple papers, including several on Aβ*56. Investigations are underway at journals, NIH, UMinnesota.
Don’t Name It: Glial States Confound Easy Labels
By consensus, leaders in the astrocyte and microglia fields recommend that investigators eschew names in favor of detailed descriptions of reactive glia, with a focus on functional changes.
In Parkinson’s, Synuclein Fibrils Fold Differently Than in MSA
Synuclein fibrils from Parkinson’s disease, PD dementia, and dementia with Lewy bodies share the same protofilament structure. MSA fibrils are different.
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