There’s No Tomorrow for TOMMORROW
The trial’s sponsor announced an early end to the large Alzheimer’s prevention study based on an interim futility analysis.
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In Familial Alzheimer’s, Tau Creeps into Cortex as Symptoms Show
In people with an autosomal-dominant AD mutation, Aβ and tau start accumulating long before the estimated onset of symptoms.
CRISPR Screen Pulls Down Fresh Targets for C9ORF72 ALS
A CRISPR knockout screen in human cells and mouse neurons found genes that tweak C9ORF72 toxicity, zeroing in on ER stress as a potential therapeutic target.
TREM2 Binds Aβ, Reprograms Microglia to Curb Plaques
Two new papers strengthen the evidence that TREM2 protects against amyloid pathology.
Human ApoE Antibody Nips Mouse Amyloid in the Bud
This alternative approach to Aβ immunotherapy targets unlipidated, plaque-associated ApoE.
In Human Neurons, ApoE4 Promotes Aβ Production and Tau Phosphorylation
Two papers report that the ApoE4 allele triggers both hallmarks of AD in iPSC-derived cultures, in contrast to its minimal effects in mouse neurons.
In New ALS/FTD Mouse Model, Poly(GR) Peptides Poison Ribosomes
Chronic inhibition of protein synthesis, and slowing the dispersal of stress granules, contribute to neurodegeneration in C9ORF72 ALS/FTD.
Nilvadipine Fails to Slow Cognitive Decline in AD Patients
Believed to be an amyloid-lowering agent, the blood pressure drug did not help people at the dementia stage of disease.
Dipeptide Repeat Proteins Trigger TDP-43 Pathology, Faulty Nuclear Import
In a fly model, C9ORF72 pathology pulls TDP-43 from the nucleus, which leads to disrupted nuclear import and neurodegeneration.
Sans Synuclein Tetramers, Mice Mimic Parkinson’s Disease
Mutations that destabilize α-synuclein tetramers leave young mice with severe and progressive motor problems resembling those of PD.
Could Rogue APP Variants Invade Genome of Individual Neurons?
In a new take on mosaicism and Alzheimer’s, scientists claim that APP mRNAs convert into DNA and reinsert into the genome. Full of mutations, these “genomic cDNAs” crop up in aging and sporadic AD.
First In Vivo Look at Amyloidosis Sparked by Dural Grafts
Researchers characterize widespread cerebral amyloid angiopathy and cortical plaques found in three living people who received dural grafts as children.
Could the Purported Muscle Exercise Hormone, Irisin, Jog Memory?
Levels of irisin are lower in brain and CSF of AD patients. Upping expression in mice protected them from synaptic deficits and memory problems.
An Antimicrobial Approach to Treating Alzheimer’s?
A periodontal pathogen found in human brains triggers AD pathology in mice. Will an antibiotic stave off dementia?
Cancer Treatment Takes Aim at Tauopathy
Building on results in AD mouse models, researchers now report that immune checkpoint inhibitors reduce pathology and improve cognition in tauopathy mice, too. Other scientists are skeptical.
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