Cholinergic Transmission and Aβ: Boosting M1 Receptors Treats Model
An impressive data set that appeared yesterday in Neuron shows that a specific M1 muscarinic receptor agonist can...
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Coping with Copper—Minute Amount of Metal Plagues Rabbit Brain
This week's PNAS early online edition reports that, depending on the diet, even minor amounts of copper can lead to both amyloid plaques and a memory deficit in rabbits...
Nicastrin—A DAPper Role in γ-Secretase
Though we've known for some time now that the protein nicastrin is a major player in the γ-secretase complex...
Presenilin—Guilty of Proteolysis by Association?
Biology rarely re-invents the wheel. That is why proponents of the idea that presenilin (PS) and the proteolytic γ-secretases are one and the same will be pleased with a paper in tomorrow's Science by Bruno Martoglio and colleagues...
From Protein Trafficking to Episodic Memory: Tracing BDNF Genotypes
An ambitious attempt to link cognitive tests, functional brain imaging, and cell biological assays implicates a polymorphism in brain-derived neurotrophic factor (BDNF) as the source for highly specific memory deficits...
Hormone Replacement Therapy Latest Entry to AlzRisk Database
Despite almost two decades of research, it is not yet clear how hormone replacement therapy affects a woman’s risk of getting Alzheimer’s disease...
Aβ, Shifty Drifter? Tissue Grafting Sheds Light on Plaque Formation
An article in the February 24 Nature Neuroscience online suggests that amyloid-β (Aβ), the peptide responsible for the intercellular plaques that appear in the brains of Alzheimer's patients, can freely diffuse through neural tissue, and that it plays a major role in the pathogenesis of the disease...
A PD Trifecta: Synuclein Gene Expression, Aging, and Inflammation
A trio of collaborators has unearthed an unlikely regulator of α-synuclein gene (SNCA) expression...
Tackling Alzheimer’s from the Outside In
Feeling good on the outside often helps us feel good on the inside. Could the same be true for neurons?...
Caught in the Act—Amyloid Damages Neurons
Since Alois Alzheimer’s first descriptions of senile plaques, we have known that they are associated with dementia. But are they detrimental?...
Dangerous Liaisons—Tau and Aβ, Together at Last?
They are no match made in heaven, but in neurons, the two proteins responsible for amyloid plaques and neurofibrillary tangles might...
SfN: The Old and the New—BACE and Cathepsin B Share the β-secretase Stage
A lively platter of slide talks on APP processing and β-secretase (BACE) activities yielded a few interesting tidbits on the...
First Crystal Structure of a Presenilin
In this week’s Nature, researchers report the first successful crystal structure of a bacterial presenilin homologue...
Alzheimer’s in a Dish? Aβ Stokes Tau Pathology in Third Dimension
Amyloid plaques and tau tangles sprout in human neuron cultures grown in a supportive gel. Researchers think this system may closely model human disease and aid in drug discovery.
On Aduhelm, Medicare Agency Gets Pressure From All Sides
The comment period ends with nearly 10,000 submissions split between pro and con, letter-writing campaigns, and scrutiny from U.S. Congress. Even so, scientists say, not much has changed.
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