Cell Death: Time to Push It Out of the Doldrums

• 10 Comments

10 Sep 2004

(Aloyz et al., 1998; Ashkenazi et al., 1998). Death domain sequences vary slightly between receptors, but

Intracellular Aβ in Alzheimer's Disease

• 3 Comments

16 May 2000

in culture (Skovronsky et al., 1998). Recently, Aβ42 accumulation was reported both in neurons in the

The Role of ApoE in Alzheimer's Disease: An Alternative View

11 Dec 2001

periphery. See (Shibata et al. 2000, Demeester et al. 2000, Rebeck et al. 1998, Koudinov et al., 2002.)

CAA: We All Know It's There, But Just What Is It Doing in Alzheimer's?

12 Mar 2003

al., 2000; Weller et al., 1998). Moreover, in transgenic mice, virtually identical amyloid-associated

New Theories of Presenilin Function

12 Dec 2000

phosphorylation and subsequent degradation of beta-catenin (Takashima et al., 1998; Zhang et al., 1998). Niwa

RNAi in Neurodegenerative Diseases—What's the Therapeutic Potential?

18 Mar 2003

1992; Cogoni et al., 1996). Since its first description in animal cells (Fire et al., 1998), a growing

Clearing the Fog Around Aβ Oligomers

• 1 Comment

14 Oct 2011

concentrations (see ARF related news story and Lambert et al., 1998). Soon, numerous other labs fingered Aβ

Weeding Mendel’s Garden: Can We Hoe Dubious Genetic Associations?

03 Aug 2012

factor for LOAD (Aldudo et al., 1998; Zekanowski et al., 2004; Helisalmi et al., 2000). Other presenilin

Now You See Them, Now You Don't: The Amyloid Channel Hypothesis

16 Jun 2005

et al., 1998; Lin et al., 1999; Lin et al., 2001; Bhatia et al., 2000). Tom Fagan So how does the

Microdissection and Microarrays: Analyzing Selective Cell Vulnerability

• 2 Comments

16 Sep 2010

Sweden, recently reported on selective cell vulnerability in motor neuron diseases (Hedlund et al., 2010).

Stress Granules and Neurodegenerative Disease—What’s the Scoop?

17 Feb 2011

knocking down (Mokas et al., 2009) or inhibiting (Kedersha et al., 1999) key translation factors, or by

Susceptibility Testing and Risk Assessment in Alzheimer Disease

01 May 2007

dementia patient. The Neurologist, 1997. 3: p. 13-30. 2. Strittmatter, W.J., et al., Apolipoprotein E:

Focus on the Locus! (Ceruleus, That Is, in Alzheimer’s Disease)

• 3 Comments

22 Dec 2010

disease (Mann et al., 1980; Bondareff et al., 1982; Haglund et al., 2006). Tau pathology also occurs in LC

Probing PPARγ? Agonists: Could Diabetes Drugs Treat Alzheimer's Disease?

• 1 Comment

16 Dec 2002

Jiang et al., 1998), together with the commercial availability of PPARγ agonists, has raised interest in

Gonadal Hormone Withdrawal, Apoptosis, and Generation of Beta Amyloid Peptide: A Vicious Cycle of Amyloidogenesis and Neurotoxicity in Alzheimer's Disease

• 5 Comments

05 Dec 2001

a correlation between serum A-β levels and AD (Mehta PD et al., 2001); Vanderstichele H., 2000). Craig Atwood: