Vascular Factors in Alzheimer's Disease
but not by apoptosis (we discussed this in Science/Nature several years ago, see Perry et al 1998 and
129 RESULTS
You searched Skovronsky et al., 1998
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but not by apoptosis (we discussed this in Science/Nature several years ago, see Perry et al 1998 and
decreases in proteasome activity in AD (Keller et al., 2000 and Keck et al., 2003, but has anyone looked
was no different than that of the animals fed ad libitum every day (see Anson et al., 2003). Howard
effects (see Orgogozo et al., 2002 and Wilcock et al., 2002). John C. Morris Bengt, Lon, Steve, Gabrielle,
protection against the Aβ toxicity (see Lovell et al., 1998). All told, the evidence points to iron- or
samples). (See Kung et al., 2002.) The data look good but we are not ready to publish yet. Bill, what's
milestone paper by Pratico et al., 2001 on isoprostanes in AD and also papers by Montine et al., 2005 and
et al., 1998; Lin et al., 1999; Lin et al., 2001; Bhatia et al., 2000). Tom Fagan So how does the
regarding your peptide inhibitor (see Sadowski et al., 2004)? In your paper, your peptide inhibits the
are very interesting! Natalie Rasgon Currently, there are studies (see, for example, Benedict et al.,
aged 78 postmortem, did not have APP pathology (see Prasher et al., 1998). She was trisomic for the
(see Constantini et al., 2005) where we show that ceramide levels increase during aging in the brain of
(Lopez et al., 2005). Eli Michaelis Thanks, June. Jens Eckstein The problem is that adoption of
deposition in APP mice, a result observed in three separate laboratories (see Patel et al., 2005 and Wang et
transgenic mouse models (Casas et al., 2004). Some neurodegenerative diseases including AD and amyotrophic
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