Could a New Down Syndrome Mouse Model Also Be Useful for Alzheimer Research?

14 Oct 2005

aged 78 postmortem, did not have APP pathology (see Prasher et al., 1998). She was trisomic for the

Protofibrillar Aβ in Alzheimer's Disease

17 Feb 2000

Dean? William Klein: Let me start by saying how much I enjoyed the paper by Dean et al. A good read.

100 Questions and Answers About Alzheimer's Disease

01 Jul 2005

regarding your peptide inhibitor (see Sadowski et al., 2004)? In your paper, your peptide inhibits the

Webinar: O Blood-Based Biomarker, Where Art Thou?

17 Jun 2013

reflect Alzheimer’s disease in the brain (see review by Toledo et al., 2013). Attempts to correlate other

How Does Excess Aβ Leave the Brain, How Does It Get In, And Can We Trap It Outside?

• 1 Comment

23 Jun 2003

hypothesis of Ab and related Ab-lowering strategies in more breadth and detail. Synposis of Deane et al

Alzheimer's: A Triple Whammy. Why are So Many Neurodegenerative Diseases Single, Double, or Triple Amyloidoses?

• 1 Comment

22 Oct 2003

concept of synaptic apoptosis developed by Mattson et al., 1998 John Q. Trojanowski One would assume

Protein Misfolding: An Unfolding Series of Discussions

09 Jun 2004

decreases in proteasome activity in AD (Keller et al., 2000 and Keck et al., 2003, but has anyone looked

Differential Neuronal Vulnerability

• 2 Comments

29 Jun 2005

disease, the mutated protein also disturbs function of skin cells in patients (according to Seo et al.,

Insulin Resistance: A Common Axis Linking Alzheimer's, Depression and Metabolism?

06 Jul 2005

are very interesting! Natalie Rasgon Currently, there are studies (see, for example, Benedict et al.,

Meet New Players, Histone Deacetylase and Sirtuin—Will They Help the Cell Cycle, DNA Repair, and Gene Expression Break Into Alzheimerology’s Major League?

• 2 Comments

10 Feb 2009

important roles of protein acetylation. I am also referring to this month’s paper by Creppe et al., 2009 on

From Epidemiology to Therapeutic Trials with Anti-inflammatory Drugs in Alzheimer's Disease: The Role of NSAIDs and Cyclooxygenase on Beta-amyloidosis and Clinical Dementia

• 4 Comments

20 Mar 2002

was the Arizona indomethacin study (Rogers et al., 1993). This was not a good study. Other therapeutic

Can Network Analysis Identify Pathological Pathways in Alzheimer’s

04 Jun 2013

this approach to identify molecular modules that might contribute to metabolic syndrome (Chen et al.,

Imaging in Alzheimer's Disease: The Current State of Affairs

27 Apr 2005

samples). (See Kung et al., 2002.) The data look good but we are not ready to publish yet. Bill, what's

Intraneuronal Aβ Accumulation—More Evidence, Less Controversy?

• 1 Comment

26 Nov 2002

out there! (See Jaworska-Wilczynska et al., 2002.) Jorge Busciglio Gunnar, you see particularly

The Functional Roles of APP Cytoplasmic Domain—Conflicts and Consensus

21 Dec 2006

Fe65 knockout (KO) mice (see Guenette et al., 2006) and Ulrike Muller showed with her APP triple KO