The Pathogen Hypothesis—Challenging the Primacy of Genetics in Late-Onset Alzheimer Disease.

• 5 Comments

22 Jan 2006

allele (Corder et al., 1998)! Objection: If pathogens cause AD, why don't we see AD brains full of

Reducing the Risk of Alzheimer Disease

23 Dec 2005

deposition in APP mice, a result observed in three separate laboratories (see Patel et al., 2005 and Wang et

Are Glia Active Participants in Neurodegenerative Disease?

• 1 Comment

05 Dec 2005

injury (see Bush et al., 1999). Gabrielle Strobel And I believe Tony Wyss-Coray has data on active

Ceramide and Cholesterol: Possible Connections Between Normal Aging of the Brain and Alzheimer’s Disease

15 Oct 2005

(see Constantini et al., 2005) where we show that ceramide levels increase during aging in the brain of

Lost in Translation? Charting the Course in Preclinical Therapeutic Development: A Panel Discussion

15 Oct 2005

(Lopez et al., 2005). Eli Michaelis Thanks, June. Jens Eckstein The problem is that adoption of

Could a New Down Syndrome Mouse Model Also Be Useful for Alzheimer Research?

14 Oct 2005

aged 78 postmortem, did not have APP pathology (see Prasher et al., 1998). She was trisomic for the

Insulin Resistance: A Common Axis Linking Alzheimer's, Depression and Metabolism?

06 Jul 2005

are very interesting! Natalie Rasgon Currently, there are studies (see, for example, Benedict et al.,

100 Questions and Answers About Alzheimer's Disease

01 Jul 2005

regarding your peptide inhibitor (see Sadowski et al., 2004)? In your paper, your peptide inhibits the

Differential Neuronal Vulnerability

• 2 Comments

29 Jun 2005

disease, the mutated protein also disturbs function of skin cells in patients (according to Seo et al.,

Now You See Them, Now You Don't: The Amyloid Channel Hypothesis

16 Jun 2005

et al., 1998; Lin et al., 1999; Lin et al., 2001; Bhatia et al., 2000). Tom Fagan So how does the

Making a BioMark on Alzheimer Disease

01 Jun 2005

milestone paper by Pratico et al., 2001 on isoprostanes in AD and also papers by Montine et al., 2005 and

Imaging in Alzheimer's Disease: The Current State of Affairs

27 Apr 2005

samples). (See Kung et al., 2002.) The data look good but we are not ready to publish yet. Bill, what's

Caloric Restriction: Eat Less, Live Longer!

• 4 Comments

31 Mar 2005

a model of amyotrophic lateral sclerosis (ALS). It is also important to consider that dietary restriction

Is Alzheimer's a Type 3 Diabetes?

• 1 Comment

25 Mar 2005

Einstein College of Medicine in 1997 (see Heitner et al., 1997) and found nothing, but it was spotty

Role and Control of Metal-Mediated Fibril Toxicity

20 Dec 2004

protection against the Aβ toxicity (see Lovell et al., 1998). All told, the evidence points to iron- or