Webinar: The NeuronDB Knowledge Base

17 Oct 2006

this Webinar on 26 October 2006. Readers are invited to submit additional comments by using our

Early Detection of Alzheimer Disease—A Virtual Town Hall Meeting

• 1 Comment

09 Jul 2008

Reply by Douglas Galasko — Posted 26 July 2008 Confidence that early-stage AD patients indeed have AD is

Webinar: Cortex Aging Too Fast? Blame TMEM106B and Progranulin

10 Apr 2017

slowing down a person’s rate of biological aging—but how to find the requisite variants? In the April 26

Seeded Aggregation and Transmissible Proteopathy—Creepy Stuff Not Just for Prions Anymore?

• 7 Comments

30 Sep 2009

26;102(17):6098-102. Abstract Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E,

Slow Aβ; Clearance Is ApoE4’s Modus Operandi in Late-Onset AD

26 Jul 2011

David Holtzman — Posted 26 July 2011 Background Text by Gabrielle Strobel ApoE reigns supreme as the

Messing with the Membrane—An Alternative Interpretation of the Amyloid-β Hypothesis

• 20 Comments

01 Nov 2006

disease. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9093-8. Copyright © 2005 National Academy of

Ceramide and Cholesterol: Possible Connections Between Normal Aging of the Brain and Alzheimer’s Disease

15 Oct 2005

a long-chain (C26) ceramide synthase. A human homolog of LAG1 can correct the phenotype in yeast, so we do have

Alzheimer's: A Triple Whammy. Why are So Many Neurodegenerative Diseases Single, Double, or Triple Amyloidoses?

• 1 Comment

22 Oct 2003

John Q. Trojanowski and Mark P. Mattson discussed the major commonality between many neurodegenerative diseases. Otherwise vastly different conditions that run the gamut from Alzheimer's, Parkinson's, Huntington's, ALS, to prion disorders,

Are Neurons Just Too Laissez-Faire about Repair?

• 1 Comment

24 Jul 2003

Thierry Nouspikel led this live discussion on 14 July 2003. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Dr. Thierry Nouspikel led this live discussion on 14 July 2003. Moderated by Dr

In Search of γ-Secretase

• 5 Comments

05 May 1999

Peter Nelson, with Dennis Selkoe, John Hardy, and Alain Israel, led this live discussion on 5 May 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion with Dennis Selkoe,

Alzheimer Immunotherapy Trial Grounded: Time to Reassess Safety and Vaccine Design

• 3 Comments

05 Mar 2002

Giulio Maria Pasinetti led this live discussion on 5 March 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page.     Background Reading by Giulio Maria Pasinetti et al. (pdf file: download free Acrob

How Does Excess Aβ Leave the Brain, How Does It Get In, And Can We Trap It Outside?

• 1 Comment

23 Jun 2003

Neurobiol Dis. 1997;4:27-34. Abstract 26. Poduslo JF, Curran GL. Amyloid-b peptide as a vaccine for

Caloric Restriction: Eat Less, Live Longer!

• 4 Comments

31 Mar 2005

Neurosci. 2003;26:81-104. Epub 2003 Jan 24. Review. Abstract Reiss AB, Siller KA, Rahman MM, Chan ES, Ghiso

Computational Modeling—Will it Rescue AD Clinical Trials?

• 1 Comment

01 May 2015

The Alzheimer's field has had its share of clinical trial flops. Now there's a push to learn from past failures. Computational scientists in pharmaceutical companies are guiding clinical trial design by first putting drug candidates through thei

Susceptibility Testing and Risk Assessment in Alzheimer Disease

01 May 2007

Alzheimer Disease. Alzheimer's Disease and Associated Disorders, 2000. 14(3): p. 129-136. Abstract 26.