Presenilin Loss of Function—Plan B for AD?

• 22 Comments

09 Mar 2007

These are comfortable times for the amyloid hypothesis, it would seem. Every week brings more good news about some anti-amyloid intervention having “cured” mice from their “Alzheimer’s.” On the human front, we are eagerly awaiting such therapeutics to sho

Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?

• 24 Comments

25 Mar 2006

We invite you to participate in this “offline” Forum discussion with past ARF advisors Peter Davies of Albert Einstein College of Medicine in the Bronx, New York, and Bart De Strooper at K.U. Leuven, Belgium. The goal of this discussion is to explore the

Alzheimer's Disease: A Re-examination of the Amyloid Hypothesis

• 1 Comment

30 Jul 2004

Peter Nelson led this live discussion on 26 March 1998. Readers are invited to submit additional

LOAD and eFAD—Different Diseases, Different Hypotheses?

05 Mar 2009

26;60(4):534-42. Abstract 0 Thursday, March 5, 2009- 00:00 Alzheimer's Disease

Are Glia Active Participants in Neurodegenerative Disease?

• 1 Comment

05 Dec 2005

Ben Barres led the first in a series of Alzforum discussions about the role of glial cells in Alzheimer’s and other neurodegenerative diseases. It has become trendy to say that glia are more than just glue, but in reality, science has not yet advanced sig

Cerebrometabolic Deficiency in Alzheimer's Disease

• 2 Comments

22 Apr 2002

J Molec Neurosci 2001;(17):361-369. Abstract. 26. Curti D, Rognoni F, Gasparini L, Cattaneo A, Paolillo M,

Calcium Signaling Deficit in the Origin of Alzheimer's Disease

• 8 Comments

07 Sep 2001

difficult to measure? Cell Calcium. 1999 Sep-Oct;26(3-4):149-54. Abstract. 9. Chen M, Durr J, Fernandez HL.

The Neuroplasticity Theory of Alzheimer's Disease

• 1 Comment

08 Apr 2002

dependent secretion of b-amyloid: roles of b-amyloid in synaptic transmission. Soc Neurosci Abstr. 26, 491

The Functional Roles of APP Cytoplasmic Domain—Conflicts and Consensus

21 Dec 2006

2001 Dec 18;98(26):14979-84. Abstract 6. Hébert SS, Serneels L, Tolia A, Craessaerts K, Derks C,

Cell Cycle Hypothesis Pedaling into Mainstream Acceptance? Results in Fly, Mouse Models Warrant a Second Look

• 4 Comments

12 Apr 2006

Vikram Khurana, Karl Herrup, Bruce Lamb, Inez Vincent, Rachael Neve, Donna McPhie, Dan Geschwind, Cathy Andorfer, and Xiongwei Zhu participated in a discussion of how far the cell cycle hypothesis has come in the past few years, and where to go next. Vik

Generation of an Apoptotic Intracellular Peptide by γ-secretase Cleavage of Alzheimer's β-amyloid Precursor Protein

20 Sep 2000

those recently published (26), which demonstrated that C31, a COOH-terminal polypeptide corresponding to

Together at Last, Top Five Biomarkers Model Stages of AD

• 4 Comments

29 Jul 2010

In this Webinar, Clifford Jack gave a slide talk summarizing a staged biomarker model of the Alzheimer’s cascade, followed by a panel discussion with Chet Mathis, David Holtzman, Henrik Zetterberg, Paul Aisen, Keith Johnson, Giovanni Frisoni, Douglas Gala

Protofibrillar Aβ in Alzheimer's Disease

17 Feb 2000

system neurotoxins. Proc Natl Acad Sci U S A 1998 May 26;95(11):6448-53. Abstract. Comments and questions

Cell Death: Time to Push It Out of the Doldrums

• 10 Comments

10 Sep 2004

system neurotoxins. Proc Natl Acad Sci U S A. 1998 May 26 ; 95(11):6448-53. Lang-Rollin IC, Rideout HJ,

Cholesterol and Alzheimer's—Charging Fast But Still at a Distance from Solid Answers

• 3 Comments

19 Nov 2002

genetics issue is covered in our Neurobiology of Lipids abstracts article Frankfurt, Germany Meeting (26