Research Models
Selected Results
1 Models
| Name | Other Names | Strain Name | Genetic Background | Gene | Mutation | Modification Info | Modification | Disease | Neuropathology | Behavior/Cognition | Other Phenotype | Availability | Primary Paper | Visualization | |
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Mouse Models (1)
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| line 13, PS1(P117L) | Mixed C57BL/6 and DBA/2J | PSEN1 | PSEN1 P117L | Transgene of human PSEN1 with the P117L mutation driven by the neuron specific enolase (NSE) promoter. | PSEN1: Transgenic | Alzheimer's Disease | No plaques or diffuse amyloid deposits at 2-3 months. Elevated generation of Aβ42. | Unknown. | Express human PSEN1 at 2-3x the level of endogenous murine PSEN1. Impaired neurogenesis in the hippocampus. | No longer available | Wen et al., 2002 | No | |||