Klunk WE, Wang Y, Huang GF, Debnath ML, Holt DP, Mathis CA.
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.
Life Sci. 2001 Aug 17;69(13):1471-84.
PubMed.
This paper should be considered a landmark in Alzheimer's research, as it laid the groundwork and provided validation for the use of members of this class of compounds as agents for non-invasive imaging of amyloid deposition in humans (Klunk et al., 2004). These techniques will provide valuable insight into the amyloid hypothesis in vivo. Perhaps more importantly, amyloid imaging may be used as a surrogate endpoint to evaluate the success of promising anti-amyloid therapies such as secretase inhibitors and immunotherapy.
References:
Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang GF, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström B.
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
Ann Neurol. 2004 Mar;55(3):306-19.
PubMed.
Comments
This paper should be considered a landmark in Alzheimer's research, as it laid the groundwork and provided validation for the use of members of this class of compounds as agents for non-invasive imaging of amyloid deposition in humans (Klunk et al., 2004). These techniques will provide valuable insight into the amyloid hypothesis in vivo. Perhaps more importantly, amyloid imaging may be used as a surrogate endpoint to evaluate the success of promising anti-amyloid therapies such as secretase inhibitors and immunotherapy.
References:
Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang GF, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström B. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol. 2004 Mar;55(3):306-19. PubMed.
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