Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, Sánchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci Transl Med. 2014 Jul 2;6(243):243ra86. PubMed.

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Comments

  1. Based on a study (Nazmi et al., 2019), TREM2 expression depends upon type I IFN-signaling and the type I IFNs are associated with neuroinflammation. Therefore, it may be important to know whether localized type I IFN production in the AD brain has any measurable effect on the levels of sTREM2.

    References:

    Nazmi A, Field RH, Griffin EW, Haugh O, Hennessy E, Cox D, Reis R, Tortorelli L, Murray CL, Lopez-Rodriguez AB, Jin L, Lavelle EC, Dunne A, Cunningham C. Chronic neurodegeneration induces type I interferon synthesis via STING, shaping microglial phenotype and accelerating disease progression. Glia. 2019 Jul;67(7):1254-1276. Epub 2019 Jan 25 PubMed.

    View all comments by Divaker Choubey

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This paper appears in the following:

Webinars

  1. Mutations Impair TREM2 Maturation, Processing, and Microglial Phagocytosis

News

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  11. New Mouse Models Reveal Unexpected Property of TREM2
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Mutations

  1. TREM2 H157Y
  2. TREM2 T66M
  3. TREM2 Q33Ter
  4. TREM2 Y38C
  5. TREM2 R47H

Research Models

  1. Trem2 T66M KI