Cao X, Südhof TC. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science. 2001 Jul 6;293(5527):115-20. PubMed.

Recommends

Please login to recommend the paper.

Comments

  1. A landmark paper demonstrating that APP intracellular domain is involved in transcriptional regulation.

    View all comments by Dominic Walsh

  2. AICD is produced after the γ-secretase proteolysis process. It is similar to NICD as a transcript factor. This paper provides us with the information that APP may function by releasing AICD. Although the target gene of AICD is still unclear, it has been attracting much attention.

    View all comments by shen chengyong

Make a Comment

To make a comment you must login or register.

This paper appears in the following:

News

  1. Long-elusive Function for APP Cleavage Product Comes into View: It's Gene Transcription
  2. Chicago: APP Roles in Caspase Gene Regulation, Muscle Function?
  3. The AICD Test? Transgenic Mice Show Neurodegeneration
  4. Brushing Up on APP—Mint-y Fresh Signaling Pathways Uncovered
  5. APP’s Better Half? Soluble Fragment Activates Protective Genes
  6. Stockholm: The Presenilin Signaling Hub—A RIP-off or the Real Deal?

Webinars

  1. How the Other Half Lives—Or the What, How, and Where of the AβPP Intracellular Domain
  2. The Functional Roles of APP Cytoplasmic Domain—Conflicts and Consensus