Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci. 2005 Oct;8(10):1343-9. PubMed.

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  1. Readers should also consult a recent paper from the laboratory of Bart De Strooper and colleagues. Their data "challenge the general idea of BACE1 as a safe drug target..."

    View all comments by George Martin

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