Su JH, Deng G, Cotman CW. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain. Brain Res. 1997 Nov 7;774(1-2):193-9. PubMed.

Recommends

Please login to recommend the paper.

Comments

    • User Profile Image Hiroshi Mori
      Osaka City University Medical School
    • Posted:

    TUNEL staining is beginning to be popular in AD research. This is the first document to explain the relationship between DNA damage and tangle formation.

    View all comments by Hiroshi Mori

  2. These data are consistent with other data (e.g. from Brad Hyman lab) suggesting that neuron death exceeds the number of NFT.

    View all comments by Paul Coleman

Make a Comment

To make a comment you must login or register.