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De Vrij FM, Sluijs JA, Gregori L, Fischer DF, Hermens WT, Goldgaber D, Verhaagen J, Van Leeuwen FW, Hol EM. Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death. FASEB J. 2001 Dec;15(14):2680-8. PubMed.
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Comments
Another mechanism of UBB+1 activity in AD? -- Eddie Koo
Boston University School of Medicine
Abnormal translation of transcripts has been reported for APP, and also for ubiquitin. This significance of these +1 proteins is unknown, but this interesting article shows that they can be toxic. When judging this work though, it is important to remember that the amount of +1 protein in the brain is much less than would be induced by a transfection. Thus, although the ubiquitin-B +1 protein has now been shown to be toxic, the effects of low level ubiquitin-B +1 on the brain remain to be determined. -- Benjamin Wolozin
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