Hefendehl JK, LeDue J, Ko RW, Mahler J, Murphy TH, MacVicar BA. Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging. Nat Commun. 2016 Nov 11;7:13441. PubMed.

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  1. These findings, along with those of McEwen and colleagues looking at riluzole, and those of Duff and colleagues looking at the role of hyperactivity in the spread of tau neuropathology in AD models, provide compelling data in support of additional preclinical studies looking at pharmacological modulation of excitatory neurotransmission as a potential therapeutic target in AD, especially if such therapeutic interventions can be initiated before the onset of overt clinical manifestations.

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