Schmitz TW, Soreq H, Poirier J, Spreng RN. Longitudinal Basal Forebrain Degeneration Interacts with TREM2/C3 Biomarkers of Inflammation in Presymptomatic Alzheimer's Disease. J Neurosci. 2020 Feb 26;40(9):1931-1942. Epub 2020 Jan 8 PubMed.

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- Pim van Gool
  Amsterdam UMC
- Posted: 20 Apr 2020
- News: Does Alzheimer’s Start in the Heart of the Cholinergic System?
The recent findings of Schmitz and colleagues on the loss of cholinergic integrity in the brain are consistent with those of Jan Willem van Dalen from our group. Based on diffusion tensor imaging and tractography in 87 memory clinic patients, van Dalen reported that degradation of the projections from the nucleus basalis of Meynert is associated with specific clinical symptoms as well as a trend for higher mortality.

References:

van Dalen JW, Caan MW, van Gool WA, Richard E. Neuropsychiatric symptoms of cholinergic deficiency occur with degradation of the projections from the nucleus basalis of Meynert. Brain Imaging Behav. 2017 Dec;11(6):1707-1719. PubMed.

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