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Coon KD, Myers AJ, Craig DW, Webster JA, Pearson JV, Lince DH, Zismann VL, Beach TG, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Walker DG, Ravid R, Heward CB, Rogers J, Papassotiropoulos A, Reiman EM, Hardy J, Stephan DA. A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. J Clin Psychiatry. 2007 Apr;68(4):613-8. PubMed.
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RIKEN Center for Brain Science
The results of this study indicate that aging and APOE4 genotype are too overwhemingly dominant risk factors for the others to be identified in aged populations. I believe that it is more practical to analyze non-familial (non-autosomal dominant) early onset (We also should keep in mind the possible presence of recessive form(s) of AD. If possible, multi-factorial analyses would be ideal. The major difficulty would be to collect a sufficient number of samples. Because China and India have so many people, one solution could be to establish international collaborations with these countries. Alternatively, we may just have to wait for the time when entire human genomes can be sequenced in a day.
References:
Abeta Metabolism and Alzheimer's Disease. (Saido, T.C. ed., 2003), Landes Bioscience (Georgetown, Tex (www.eurekah.com)).
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