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Sebastiani P, Solovieff N, Dewan AT, Walsh KM, Puca A, Hartley SW, Melista E, Andersen S, Dworkis DA, Wilk JB, Myers RH, Steinberg MH, Montano M, Baldwin CT, Hoh J, Perls TT. Genetic signatures of exceptional longevity in humans. PLoS One. 2012;7(1):e29848. PubMed.
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23andme, Inc.
This new paper addresses some of the issues raised by the authors' retracted study, but some methodological issues remain that call into question the conclusions the authors offer. The finding of an association between longevity and a variant in ApoE is convincing, but we were not able to replicate their more complex 281-SNP model in the 23andMe participant cohort. Longevity is a difficult trait for testing genetic risk models because we know so little about its genetics. We think the authors' methodology might be better tested on a trait where we already know more about genetic risk factors, so other approaches could be more easily compared.
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