Llorens F, Kruse N, Schmitz M, Gotzmann N, Golanska E, Thüne K, Zejneli O, Kanata E, Knipper T, Cramm M, Lange P, Zafar S, Sikorska B, Liberski PP, Mitrova E, Varges D, Schmidt C, Sklaviadis T, Mollenhauer B, Zerr I. Evaluation of α-synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases. Alzheimers Dement. 2016 Nov 18; PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
tau-p181
(CSF)		 AD
(65)		 81 ± 46
pg/mL		 ELISA;
Innotest;
Fujirebio		 1991
tau-p181
(CSF)		 PD
(53)		 41 ± 16
pg/mL		 ELISA;
Innotest;
Fujirebio		 1991
tau-total
(CSF)		 AD
(65)		 601 ± 421
pg/mL		 ELISA;
Innotest;
Fujirebio		 1991
tau-total
(CSF)		 FFI
(18)		 623 ± 197
pg/mL		 ELISA;
Innotest;
Fujirebio		 Zerr et al., 2009
tau-total
(CSF)		 gCJD-
E200K
(27)		 8545 ± 6495
pg/mL		 ELISA;
Innotest;
Fujirebio		 Zerr et al., 2009
α-synuclein
(CSF)		 AD
(65)		 354 ± 277
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
In-house		 1991
α-synuclein
(CSF)		 DLB
(11)		 220 ± 61
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
In-house		 McKeith et al., 1996
α-synuclein
(CSF)		 PD
(53)		 201 ± 55
pg/mL		 Electrochemiluminescence;
Other/Not Specified;
In-house		 1991

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This paper appears in the following:

AlzBiomarker

  1. PD vs AD : tau-p181 (CSF)
  2. FFI vs AD : tau-total (CSF)
  3. gCJD vs AD : tau-total (CSF)
  4. DLB vs AD : α-synuclein (CSF)
  5. PD vs AD : α-synuclein (CSF)