Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18;280(7):5892-901. PubMed.

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Comments

  1. Curcumin also impacts aluminum binding to chromatin DNA, which is of relevance. After aluminum mordanting of chicken blood smears, several chelating dyes and reagents were found to detect metal binding to chromatin DNA by fluorescence microscopy. One of them [the reagents] was curcumin. Aluminum is a risk factor for AD.

    References:

    Llorente AR, Del Castillo P, Stockert JC. Aluminium binding to chromatin DNA as revealed by formation of fluorescent complexes with 8-hydroxyquinoline and other ligands. J Microsc. 1989 Aug;155(Pt 2):227-30. PubMed.

    View all comments by Erik Jansson

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