De Vos A, Struyfs H, Jacobs D, Fransen E, Klewansky T, De Roeck E, Robberecht C, Van Broeckhoven C, Duyckaerts C, Engelborghs S, Vanmechelen E. The Cerebrospinal Fluid Neurogranin/BACE1 Ratio is a Potential Correlate of Cognitive Decline in Alzheimer's Disease. J Alzheimers Dis. 2016 Jul 6;53(4):1523-38. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ38
(CSF)		 AD
(50)		 1419 ± 436
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 2011
Aβ38
(CSF)		 CTRL-
CNC
(20)		 1711 ± 632
pg/mL §		 ELISA;
Other/Not Specified;
In-house
Aβ40
(CSF)		 AD
(50)		 6191 ± 2823
pg/mL §		 ELISA;
Beta-Amyloid (1-40);
Euroimmun		 McKhann et al., 2011
Aβ40
(CSF)		 CTRL-
CNC
(20)		 7478 ± 2742
pg/mL §		 ELISA;
Beta-Amyloid (1-40);
Euroimmun
neurogranin
(CSF)		 AD
(50)		 192 ± 77
pg/mL §		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 2011
neurogranin
(CSF)		 CTRL-
CNC
(20)		 159 ± 68
pg/mL §		 ELISA;
Other/Not Specified;
In-house

§ Data supplied to Alzforum by author

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This paper appears in the following:

AlzBiomarker

  1. AD vs CTRL : Aβ38 (CSF)
  2. CTRL vs AD : Aβ38 (CSF)
  3. AD vs CTRL : Aβ40 (CSF)
  4. CTRL vs AD : Aβ40 (CSF)
  5. AD vs CTRL : neurogranin (CSF)
  6. CTRL vs AD : neurogranin (CSF)