De Vos A, Jacobs D, Struyfs H, Fransen E, Andersson K, Portelius E, Andreasson U, De Surgeloose D, Hernalsteen D, Sleegers K, Robberecht C, Van Broeckhoven C, Zetterberg H, Blennow K, Engelborghs S, Vanmechelen E. C-terminal neurogranin is increased in cerebrospinal fluid but unchanged in plasma in Alzheimer's disease. Alzheimers Dement. 2015 Jun 16; PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
neurogranin
(CSF)		 AD
(20)		 41 ± 27
pg/mL §		 ELISA;
In-house;
In-house		 McKhann et al., 2011
neurogranin
(CSF)		 CTRL-
CNC
(29)		 15 ± 17
pg/mL §		 ELISA;
In-house;
In-house
neurogranin
(Plasma)		 AD
(20)		 2.77 ± 4.92
ng/mL §		 ELISA;
In-house;
In-house		 McKhann et al., 2011
neurogranin
(Plasma)		 CTRL-
CNC
(29)		 4.12 ± 6.68
ng/mL §		 ELISA;
In-house;
In-house
tau-total
(Plasma)		 AD
(20)		 40.2 ± 63.1
AU §		 ELISA;
In-house;
In-house		 McKhann et al., 2011
tau-total
(Plasma)		 CTRL-
CNC
(29)		 24.6 ± 33.6
AU §		 ELISA;
In-house;
In-house

§ Data supplied to Alzforum by author

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  5. AD vs CTRL : tau-total (Plasma and Serum)
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