Fernández-Cabello S, Kronbichler M, Van Dijk KR, Goodman JA, Spreng RN, Schmitz TW, Alzheimer’s Disease Neuroimaging Initiative. Basal forebrain volume reliably predicts the cortical spread of Alzheimer's degeneration. Brain. 2020 Mar 1;143(3):993-1009. PubMed.

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  1. The recent findings of Schmitz and colleagues on the loss of cholinergic integrity in the brain are consistent with those of Jan Willem van Dalen from our group. Based on diffusion tensor imaging and tractography in 87 memory clinic patients, van Dalen reported that degradation of the projections from the nucleus basalis of Meynert is associated with specific clinical symptoms as well as a trend for higher mortality.

    References:

    van Dalen JW, Caan MW, van Gool WA, Richard E. Neuropsychiatric symptoms of cholinergic deficiency occur with degradation of the projections from the nucleus basalis of Meynert. Brain Imaging Behav. 2017 Dec;11(6):1707-1719. PubMed.

    View all comments by Pim van Gool

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