von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci. 2004 Sep 1;117(Pt 19):4435-48. PubMed.

Comments

- Andre Delacourte
  Inserm
- Posted: 06 Sep 2004
From this paper, one should ask—if AICD is dysregulated in AD—if yes, if this dysregulation is playing a role in the neurodegenerating process (loss of function of APP due to aberrrant nuclear signalling), and if amyloid is not a marker of this dysmetabolism.

View all comments by Andre Delacourte

Make a Comment

To make a comment you must login or register.

Paper

Tools

Comments

Make a Comment

This paper appears in the following:

News