Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L. Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions. Cell. 2017 Jul 27;170(3):443-456.e14. PubMed. Correction.
Recommends
Please login to recommend the paper.
This paper appears in the following:
Mutations
News
- Semagacestat, a Pseudo γ-Secretase Inhibitor?
- CryoEM γ-Secretase Structures Nail APP, Notch Binding
- Familial Alzheimer’s Mutations: Different Mechanisms, Same End Result
- γ-Secretase Revisited—Could Selective Inhibitors Treat AD, Cancer Safely?
- Are the Long Aβ Peptides the Real Bad Guys?
- Ratio of Short to Long Aβ Peptides: Better Handle on Alzheimer's than Aβ42/40?
- Patricidal Protein? Aβ42 said to Inhibit Its Parent, γ-Secretase
Comments
No Available Comments
Make a Comment
To make a comment you must login or register.