The center accepts brain donations from Alzheimer's patients and cognitively normal controls who were seen at the center before death (family members can call the office to discuss feasibility of other donations). Samples available to researchers include brain tissue as paraformaldehyde-fixed wet tissue, paraffin blocks thereof, frozen unfixed, and unstained sections from selected regions; plasma from blood samples obtained from living subjects and controls; DNA extracted from leukocytes of blood samples from living individuals; and some postmortem CSF.