Antibody

MOAB-2

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Clonality: monoclonal
Host: Mouse
Isotype: IgG2b
Source: Novus Biologicals
Catalog #: NBP-2-13075
Formulation: Protein G purified; Tris-glycine buffer with 150mM NaCl and 0.05% Sodium Azide; pH 7.5
Reactivity:
Reacts in: Human, Mouse, Rat
Availability: Confirmed available March 2015.

Immunogen/Epitope

Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF)

Specificity

Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs.

Note

Originally generated by Mary Jo LaDu and colleagues at the University of Illinois.

This antibody is available in a variety of formats, including conjugated to biotin, HRP, FITC, and other fluorophores.

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References

Other Citations

  1. Mary Jo LaDu

Further Reading

Papers

  1. Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, Weeber EJ, Bu G, Yu C, LaDu MJ. APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease. J Biol Chem. 2012 Dec 7;287(50):41774-86. PubMed.
  2. Kim JA, Yun HM, Jin P, Lee HP, Han JY, Udumula V, Moon DC, Han SB, Oh KW, Ham YW, Jung HS, Song HS, Hong JT. Inhibitory effect of a 2,4-bis(4-hydroxyphenyl)-2-butenal diacetate on neuro-inflammatory reactions via inhibition of STAT1 and STAT3 activation in cultured astrocytes and microglial BV-2 cells. Neuropharmacology. 2014 Apr;79:476-87. Epub 2013 Jul 23 PubMed.