Antibody

MOAB-2

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Clonality: monoclonal
Host: Mouse
Isotype: IgG2b
Source: Biosensis
Catalog #: M-1586-100
Formulation: Lyophilized; Protein A purified; 0.02 M potassium phosphate, 0.15 M sodium chloride, 0.01% sodium azide; pH 7.2
Reactivity:
Reacts in: Human, Rat
Availability: Confirmed available March 2015.

Immunogen/Epitope

Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF)

Specificity

Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs.

Note

Originally generated by Mary Jo LaDu and colleagues at the University of Illinois.

ELISA kits using this MOAB-2 are also available (e. g., Oligomeric Aβ kit and ApoE/Aβ Complex).

Comments / Questions

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References

Other Citations

  1. Mary Jo LaDu

External Citations

  1. Oligomeric Aβ kit
  2. ApoE/Aβ Complex

Further Reading

Papers

  1. Youmans KL, Tai LM, Nwabuisi-Heath E, Jungbauer L, Kanekiyo T, Gan M, Kim J, Eimer WA, Estus S, Rebeck GW, Weeber EJ, Bu G, Yu C, LaDu MJ. APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease. J Biol Chem. 2012 Dec 7;287(50):41774-86. PubMed.
  2. Tai LM, Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, LaDu MJ. Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples. J Biol Chem. 2013 Feb 22;288(8):5914-26. PubMed.
  3. Zhao W, Dumanis SB, Tamboli IY, Rodriguez GA, Jo Ladu M, Moussa CE, William Rebeck G. Human APOE Genotype Affects Intraneuronal Aβ1-42 Accumulation in a Lentiviral Gene Transfer Model. Hum Mol Genet. 2013 Nov 6; PubMed.
  4. Kunzler J, Youmans KL, Yu C, Ladu MJ, Tai LM. APOE modulates the effect of estrogen therapy on Aβ accumulation EFAD-Tg mice. Neurosci Lett. 2014 Feb 7;560:131-6. Epub 2013 Dec 22 PubMed.
  5. Rodriguez GA, Tai LM, LaDu MJ, Rebeck GW. Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition. J Neuroinflammation. 2014 Jun 19;11:111. PubMed.
  6. Tai LM, Koster KP, Luo J, Lee SH, Wang YT, Collins NC, Ben Aissa M, Thatcher GR, LaDu MJ. Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo. J Biol Chem. 2014 Oct 31;289(44):30538-55. Epub 2014 Sep 12 PubMed.