Alzpedia
Progranulin
Synonyms: GRN, PGRN, granulin precursor, granulin, proepithelin, PC cell-derived growth factor (PCDGF), GP88, PEPI, CLN11, Granulin Epithelin Precursor (GEP)
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News
- Does Progranulin Play Both Sides in AD and FTD?
- Can Epigenetics Explain Variable Progranulin Expression?
- Birds of a Feather…Mutations in Tau Gene Neighbor Progranulin Cause FTD
- FTD Risk Factor Confirmed, Alters Progranulin Pathways
- Microglial Progranulin Douses Neural Inflammation
- Could Sortilin Be a Sweet Spot for FTD Therapy?
Papers
- Perry DC, Lehmann M, Yokoyama JS, Karydas A, Lee JJ, Coppola G, Grinberg LT, Geschwind D, Seeley WW, Miller BL, Rosen H, Rabinovici G. Progranulin mutations as risk factors for Alzheimer disease. JAMA Neurol. 2013 Jun 1;70(6):774-8. PubMed.
- Cenik B, Sephton CF, Kutluk Cenik B, Herz J, Yu G. Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration. J Biol Chem. 2012 Sep 21;287(39):32298-306. PubMed.
- Rademakers R, Neumann M, Mackenzie IR. Advances in understanding the molecular basis of frontotemporal dementia. Nat Rev Neurol. 2012 Jun 26;8(8):423-34. PubMed.
- Gass J, Prudencio M, Stetler C, Petrucelli L. Progranulin: An emerging target for FTLD therapies. Brain Res. 2012 Jan 28; PubMed.
- Kumar-Singh S. Progranulin and TDP-43: mechanistic links and future directions. J Mol Neurosci. 2011 Nov;45(3):561-73. PubMed.