Can Aβ Seeds Be Transferred During Neurosurgery?
Researchers claim that young cases of cerebral amyloid angiopathy may have been caused by contaminated surgical equipment.
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Confirmed: Human Pituitary Extract Linked to Amyloidosis Contains Aβ Seeds
The material, previously used to treat children with growth deficiencies, triggered amyloid deposition in transgenic mice.
BACE and γ-Secretase Form Mega-Complex that Processes APP
Are high-molecular-weight, multi-protease complexes cellular Aβ factories?
Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80
Scientists propose that LATE is a neurodegenerative disease marked by TDP-43 pathology in limbic regions, and memory loss. After death, it can be seen alone or with other pathology.
It Bleeds! New Mini-Brains Sport Functioning Blood Vessels
Researchers induced cortical organoids to grow their own vasculature and even form a blood-“brain” barrier, making the little blobs more useful for studying disease.
Do World Trade Center Responders Get Early Onset Plaques and Tangles?
Middle-aged WTC responders have cognitive problems, which correlate not only with their PTSD symptoms and exposure to toxic dust, but also with biomarkers of amyloid and tau.
Plaques, Tangles Throw Off the Brain’s Rhythms
In the human brain, alpha waves fell out of sync, while delta-theta waves swelled in concert with amyloid plaques, neurofibrillary tangles. Alpha modulation correlated with cognitive decline.
Does Second X Chromosome Boost Women’s Resilience Against Alzheimer’s?
In female mice it’s the other X chromosome, not lack of a Y, that extends life and preserves memory in the face of amyloidosis. A histone demethylase gene partly explains this. It protects people, too.
IFITM3 Forges Link Between Neuroinflammation and Aβ Production
The antiviral protein enhances γ-secretase processing of APP. More of it is present in Alzheimer’s disease.
In Preclinical Alzheimer’s, Learning Falters Before Memory
Learning tests may prove more informative in clinical trials of early AD. A new one claims it can spot a difference in six days.
VCP Coding Mutation Causes a Tauopathy With Vacuoles
Carriers of a rare hypomorphic gene variant develop a frontotemporal dementia that features Alzheimer’s-like neurofibrillary tangles.
In Astrocytes, ApoE4 Bungles Endocytosis, PICALM Picks Up the Slack
The first steps of endocytosis faltered in astrocytes expressing ApoE4, but pumping in PICALM reversed the problem. A new study places two Alzheimer’s risk factors into the same cellular mechanism.
FDA Advisory Committee Throws Cold Water on Aducanumab Filing
The panel considered the evidence for efficacy to be weak, and was troubled by too-close collaboration between the sponsor and the FDA.
Does Calcium Overload Mark Dendritic Spines for Destruction?
In a mouse model of cortical multiple sclerosis, microglia and monocytes swooped in to gobble up synapses when dendritic calcium rose. Spines grew back once inflammation subsided.
Herpes Update—Virus Increases Dementia Risk in Sweden
Epidemiology study reveals 1.5-times higher risk of dementia after herpes virus infection. Short-term antiviral treatment appears to lower risk.
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