Aβ Star is Born? Memory Loss in APP Mice Blamed on Oligomer
In a clever bit of sleuthing, Karen Ashe and colleagues appear to have solved the case of the mysterious...
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Mutant Presenilin Knock-in Mice Mimic Knockouts, Stir Old Debate
Mice expressing presenilin harboring AD-associated mutations resemble mice lacking the enzyme altogether, suggesting that the mutations fully inactivate the enzyme.
Cerebrospinal Fluid Neurogranin Correlates with Markers of Neurodegeneration
Levels of CSF biomarker neurogranin correlate with imaging measures of synaptic integrity in ADNI cohort.
Lilliputian Effect Size Fells Phase 3 Trial of Solanezumab, Leaving Its Future Uncertain
Eli Lilly has given up on regulatory submission for mild AD, but leaves door open to seeking approval for earlier disease stages if three ongoing studies succeed.
CTAD: Solanezumab Seen to Nudge AD Ever so Slightly
Patients on solanezumab saw small improvements on multiple secondary endpoints.
Hot DAM: Specific Microglia Engulf Plaques
The transcriptomes of single immune cells in the mouse brain identify specific disease-associated microglia (DAM), which eat away at Aβ deposits.
Does Lithium in Tap Water Keep Dementia at Bay?
Danish study correlates higher natural levels of lithium to lower incidence of Alzheimer’s disease
Amyloid-β Fibril Structure Bares All
CryoEM reveals high-resolution view of full length of Aβ42 in a novel conformation.
Can Aβ Seeds Be Transferred During Neurosurgery?
Researchers claim that young cases of cerebral amyloid angiopathy may have been caused by contaminated surgical equipment.
Confirmed: Human Pituitary Extract Linked to Amyloidosis Contains Aβ Seeds
The material, previously used to treat children with growth deficiencies, triggered amyloid deposition in transgenic mice.
BACE and γ-Secretase Form Mega-Complex that Processes APP
Are high-molecular-weight, multi-protease complexes cellular Aβ factories?
Introducing LATE—A Common TDP-43 Proteinopathy that Strikes After 80
Scientists propose that LATE is a neurodegenerative disease marked by TDP-43 pathology in limbic regions, and memory loss. After death, it can be seen alone or with other pathology.
It Bleeds! New Mini-Brains Sport Functioning Blood Vessels
Researchers induced cortical organoids to grow their own vasculature and even form a blood-“brain” barrier, making the little blobs more useful for studying disease.
Do World Trade Center Responders Get Early Onset Plaques and Tangles?
Middle-aged WTC responders have cognitive problems, which correlate not only with their PTSD symptoms and exposure to toxic dust, but also with biomarkers of amyloid and tau.
Plaques, Tangles Throw Off the Brain’s Rhythms
In the human brain, alpha waves fell out of sync, while delta-theta waves swelled in concert with amyloid plaques, neurofibrillary tangles. Alpha modulation correlated with cognitive decline.
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