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For many families caring for an Alzheimer's patient, it is not the memory impairment per se that drives them to place their loved one in a nursing home, so much as the agitation, aggression and even violence that demented patients frequently exhibit...
Stress and glucocorticoids (hormones produced in response to stress) are known to impair the acquisition and storage of new information. But stress also hinders the ability to recall memories...
It has been theorized that cell membranes contain stable regions consisting of glycolipids and cholesterol. They are called detergent-insoluble glycolipid-enriched membrane domains (DIGs)...
Transcription factors of the nuclear factor-kB/rel (NF-kB) family may be important in cell survival by regulating unidentified, antiapoptotic genes. One such gene that protects cells from apoptosis...
Acetylcholine has different effects on the excitability of different neuronal types, according to work by Xiang, et al, published in today's Science. The researchers examined two subtypes of interneurons in layer V of rat visual cortex...
Maybe it is time to give up steak in order to live longer—at least if you are a fruit fly. According to a study published today in Science, a diet of sugar keeps flies in a metabolic "waiting mode," in which both reproduction and death rates are low...
An enzyme in <em>Caenorhabditis elegans</em> affects the rate at which the dainty worms age, by modulating the cellular response to oxidative stress...
Because presenilin was discovered in positional cloning experiments involving large familial Alzheimer's disease kindreds, there were no previous data concerning its biological function. As a result...
A study published last year by Margaret Pericak-Vance et al. (JAMA 1997;278) reported a putative locus for late-onset Alzheimer's disease (LOAD) at chromosome 12p11-12, and set off a race to confirm and nail down the gene...
Yamaguchi (Abstract 1245) presented his theory that very diffuse plaques within nondemented individuals are cleared by astrocytic phagocytosis. He showed many examples of very diffuse Aβ-positive staining...
A new epidemic of "mad tau disease" swept Amsterdam at the workshop on Hereditary Fronto-Temporal Dementia and Pick's disease. Fronto-temporal dementia and Parkinsonism linked to chromosome 17...
While a number of drug companies have been pumping big bucks into creating novel molecules capable of inhibiting formation of Aβ fibrils, along comes Alan Snow and his colleagues...
If you came to Amsterdam hoping to hear a lot of new data on Aβ peptide inhibitors, you might have learned more by window shopping in the red-light district...
Over a decade ago, John Blass and his colleagues proposed that AD was caused by compromised metabolism. Today, this theory has gained support from a convergence of numerous...
The focus of this symposium was the biology and diagnostic value of a recently discovered protein, termed AD7c-neuronal thread protein (NTP), in Alzheimer's disease...
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