ApoE4 Testing Rejected by Ethics Panel
Genetic testing for the ApoE allele should not be used to aid diagnosis of the sporadic form of Alzheimer's disease, concludes a Stanford University biomedical ethics committee...
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Aging and Pathology Interacting in the Cholinergic System
The "cholinergic hypothesis" of cognition places emphasis on the role of cholinergic neurons in the basal forebrain and their projections to cortical areas...
A Note of Caution about COX-2 Inhibitors
Hopes have been raised that drugs which inhibit the proinflammatory COX-2 enzyme could be effective in treating rheumatoid arthritis and perhaps also Alzheimer's disease...
The A2M Deletion, Revisited
Last year Deborah Blacker, Rudolph Tanzi and their colleagues reported finding a strong association between a deletion of exon 18 in the gene for α2 macroglobulin (A2M) and Alzheimer's disease...
Biochemical Mechanisms of Long-Term Memory
Evidence from several sources suggests that the dorsal hippocampus is critical for the formation and storage of spatial information. In the long term, such information is believed to be transferred to the neocortex for storage...
Of Presenilins and Armadillos
The armadillo gene—so named because its mutated form in fruit flies produces a phenotype with short spiky hairs, reminiscent of those on the armadillo—codes for a protein that is a homologue of the human β-catenin...
Vitamin E: More Than an Antioxidant?
Atherosclerotic processes are drawing the attention of some Alzheimer's researchers who point to a number of links between atherosclerotic disease and Alzheimer's disease...
Can Functional MRI Predict Alzheimer's Disease?
At the American Academy of Neurology meeting in Toronto, Scott Small and colleagues presented data suggesting that fMRI can distinguish early AD-related memory decline from other sources of memory decline...
More Clues in the Case, but γ-Secretase Remains at Large
In the search for the elusive γ-secretase that cleaves β-amyloid precursor protein (APP), much attention has been paid to the protein Notch, which is critical in developmental pathways...
Watching Enzymes at Work
Three-dimensional images of enzymes at work in cells? This is the promise of a new advance in microscopy called fluorescence lifetime imaging microscopy (FLIM)...
Making Dirty RNA from Clean DNA
Fred Van Leeuwen and his colleagues reported last year (Science 9 Jan 1998;279:242-7) that some neurons in Alzheimer's patients contain mutant RNA coding for APP and ubiquitin...
More Details to the β-catenin Picture
β-catenin, a protein that regulates transcription, has drawn attention in Alzheimer's research because it interacts with PS1 and PS2. It was also recently found that AD patients with the PS1 mutation have markedly reduced β-catenin...
Abnormal Motion Processing in AD
It has long been assumed that the reason Alzheimer's patients tend to get lost is because of memory failure and confusion. But a new study appearing in tomorow’s issue of Neurology suggests that impaired processing of visual information...
Prion Soup
Researchers in the U.K. have created conditions inside a test tube in which human prion protein can flip back and forth between normal forms and abnormal forms associated with neurodegenerative disease...
Human ApoE Slows Plaque Deposition in Tg Mice
Ever since the ApoE4 allele was identified as a risk factor in late-onset Alzheimer's, researchers have speculated that ApoE interacts with β-amyloid. Several years ago, Kelly Bales and colleagues at Lilly Research Laboratories...
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