Mesh, not Membrane: Pia Filters CSF, Gets Clogged by Aβ Fibrils
New data show the pia is a permeable mesh that filters CSF and harbors macrophages. It thins with age but thickens in a mouse model of amyloidosis.
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Do a Few “Master” Sites Control Tau Hyperphosphorylation?
Phospho groups at key residues, such as threonine 181, promoted phosphorylation at multiple distant sites along the protein, suggesting a regulatory role.
In the U.S., 40 Percent of All-Cause Dementia Is Preventable
Obesity, hypertension, and physical inactivity account for one in five cases.
In Down's Syndrome, Blood P-Tau217 Detects Plaques and Tangles
In young adults with Down’s, plasma phospho-tau217 correlated with amyloid and tau PET positivity. With great accuracy.
Too Clingy: Extra Hydrogen Bond Prompts Protein Aggregation
Certain mutations in TDP-43, tau, and NfL add one hydrogen bond to their low-complexity domains. This warps phase transition and strengthens self-aggregation.
CAPturing Oligomers from Biofluids
With its affinity for β-sheets, a probe called Capture Molecule for Amyloid Precipitation, aka CAP-1, pulls α-synuclein and other soluble amyloids out of solution.
Lecanemab: FDA Set Accelerated Approval Decision for January 2023
The agency accepted Eisai and Biogen’s application for priority review under the accelerated approval pathway, based on Phase 2 biomarker data.
A Putrid Problem: Astrocytic Urea Cycle in Alzheimer’s?
In astrocytes, Aβ revs up urea metabolism, spitting out the intermediate putrescine. This gets turned into the neurotransmitter GABA, which blunts synaptic transmission and memory in mice.
Astrocyte-to-Neuron Conversion Questioned
A spate of recent studies could not replicate the finding that knocking down the RNA-binding protein PTBP1 in astrocytes triggers their conversion to neurons. Leaky expression of the knockdown construct in endogenous neurons may be to blame.
Destined to Decline: Plaque-Tangle Combo Foretells Impairment
Cognitively normal people whose PET scans showed both plaques and tangles slid toward MCI or dementia within a few years. This risk was 19 times higher than in people without these deposits.
Astrocyte Reactivity: Opposing States Emerge
Astrocytes react differently depending on the type of insult or injury inflicted upon the brain. Two studies identified transcriptional regulators controlling astrocyte responses.
Digital Tools Abound, Yet Remote Biomarkers for FTD Remain Exploratory
At the Holloway Summit, scientists, regulatory, and foundation leaders discussed how to advance digital biomarkers from the idea stage into standardized, reliable tools for diagnosis and trials.
Digital Biomarkers of FTD: How to Move from Tech Tinkering to Trials?
The inaugural Holloway Summit, hosted by AFTD, focused on the development of digital health technologies to track the progression of FTD’s myriad manifestations.
AFTD Holloway Summit 2022: Digital Assessment Tools for FTD
Digital Biomarkers of FTD: How to Move from Tech Tinkering to Trials? Digital Tools Abound, Yet Remote Biomarkers for FTD Remain Exploratory Changes in activity, speech, sleep, or the way a person moves are all examples of measurements that can be capture
C1q Shows Promise as Therapeutic Target to Stop Synapse Loss
A C1q antibody hit its target in a small Phase 2 Huntington’s trial, while indirect inhibition of C1q restored synaptic density in Alzheimer’s model mice.
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