Paper on α-Secretase Regulation Retracted
Researchers claim basic conclusions still sound.
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Scientists Propose a New Definition for Tau-Only Pathology
Term covers tauopathy in the absence of Aβ, regardless of cognitive state.
Geriatric Astrocytes Fail Motor Neurons in ALS Model
Trophic factor may rejuvenate aging cells and protect neurons.
Epigenetic Alterations Mark Alzheimer’s Disease Genes
Researchers detect aberrant methylation in genome regions that associate with late-onset AD.
First Data from GENFI1: Brain’s Insula Region Shrinks A Decade Before FTD
Confirming hints from case reports, the Genetic FTD Initiative, a European-Canadian frontotemporal dementia network, shows which brain areas change long before tau, progranulin, and C9ORF72 mutation carriers become symptomatic.
Meet the Artful Leftie: NIH Jump-Starts U.S.-Canadian FTLD Cohorts
Not to be outdone by ongoing FTLD cohort studies underway mostly in Europe, U.S.-Canadian studies are now forging structured networks to track presymptomatic and symptomatic cases and to engage a panoply of funders and advocacy groups in a clinical trials initiative.
German Network of 700 FTLD Patients Presents Baseline Data
You might not think it possible to assemble large, longitudinal cohorts of loyal study subjects for rare dementias marked by apathy and emotional blunting. Think again—at the International Conference for Frontotemporal Dementia, researchers showed that they just did it.
Progranulin-Boosting Drug Moves into Phase 2 for Frontotemporal Dementia
FORUM Pharmaceuticals announced that its histone deacetylase inhibitor has passed a Phase 1 trial, and will advance to Phase 2 immediately. It was one of two trials presenting data on active investigational drugs at ICFTD.
Older Adults Get No Cognitive Boost From B Vitamins
In a two-year study, a heaping dose of vitamin B did nothing to sharpen cognition in people over 65, casting further doubt on the supplement’s ability to stave off dementia.
Do Alzheimer’s GWAS Hits Speed Up Disease?
Variants in the genome that increase the risk for Alzheimer’s also lower the age of onset.
Cloak and Dagger Clusters? How C9ORF72 Repeats Kill Is Still a Mystery
In debating how C9ORF72 causes neurodegeneration, researchers struggle to connect cell-culture results with divergent patterns of human disease.
Stream of Genetics Pushes FTD Research Forward
At ICFTD, researchers proposed new genes and explored genetic differences that contribute to the vast diversity of FTD clinical presentations.
Do MicroRNAs Cause Mayhem Across Frontotemporal Dementia Spectrum?
Whether by themselves or in the company of mutations that cause frontotemporal dementia, microRNAs may play a hand in driving disease.
The Epidemic in Your Head? New Model Casts Amyloid as Intra-Brain Contagion
Aβ and other pathogenic proteins may cause neurodegenerative disease by spreading throughout the brain like infectious diseases spread through populations, according to a new mathematical model.
Ready or Not: Stem Cell Therapies Poised to Enter Trials for Alzheimer’s
At Duke University, researchers discussed how injected stem cells might be tracked and used to treat neurodegenerative diseases.
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